Inhibition of brain tumor cell proliferation by alternating electric fields

Hyesun Jeong; Jiwon Sung; Seung Ick Oh; Seonghoon Jeong; Eui Kwan Koh; Sunghoi Hong; Myonggeun Yoon

doi:10.1063/1.4902112

Inhibition of brain tumor cell proliferation by alternating electric fields

Hyesun Jeong, Jiwon Sung, Seung Ick Oh, Seonghoon Jeong, Eui Kwan Koh, Sunghoi Hong, Myonggeun Yoon

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

This study was designed to investigate the mechanism by which electric fields affect cell function, and to determine the optimal conditions for electric field inhibition of cancer cell proliferation. Low-intensity (<2 V/cm) and intermediate-frequency (100-300 kHz) alternating electric fields were applied to glioblastoma cell lines. These electric fields inhibited cell proliferation by inducing cell cycle arrest and abnormal mitosis due to the malformation of microtubules. These effects were significantly dependent on the intensity and frequency of applied electric fields.

Original language	English
Article number	203703
Journal	Applied Physics Letters
Volume	105
Issue number	20
DOIs	https://doi.org/10.1063/1.4902112
Publication status	Published - 2014 Nov 17

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1063/1.4902112

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AU - Jeong, Hyesun

AU - Sung, Jiwon

AU - Oh, Seung Ick

AU - Jeong, Seonghoon

AU - Koh, Eui Kwan

AU - Hong, Sunghoi

AU - Yoon, Myonggeun

PY - 2014/11/17

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N2 - This study was designed to investigate the mechanism by which electric fields affect cell function, and to determine the optimal conditions for electric field inhibition of cancer cell proliferation. Low-intensity (<2 V/cm) and intermediate-frequency (100-300 kHz) alternating electric fields were applied to glioblastoma cell lines. These electric fields inhibited cell proliferation by inducing cell cycle arrest and abnormal mitosis due to the malformation of microtubules. These effects were significantly dependent on the intensity and frequency of applied electric fields.

AB - This study was designed to investigate the mechanism by which electric fields affect cell function, and to determine the optimal conditions for electric field inhibition of cancer cell proliferation. Low-intensity (<2 V/cm) and intermediate-frequency (100-300 kHz) alternating electric fields were applied to glioblastoma cell lines. These electric fields inhibited cell proliferation by inducing cell cycle arrest and abnormal mitosis due to the malformation of microtubules. These effects were significantly dependent on the intensity and frequency of applied electric fields.

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Inhibition of brain tumor cell proliferation by alternating electric fields

Abstract

ASJC Scopus subject areas

UN SDGs

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