Inhibition of Melanogenesis by Essential Oils from the Citrus Cultivars Peels

Jiyoon Yang, Su Yeon Lee, Soo Kyeong Jang, Ki Joong Kim, Mi Jin Park

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Citrus is one of the most popular and widely grown fruit crops in the world. However, the bioactivity of only certain species of citrus cultivars is studied. In this study, the effects of essential oils from 21 citrus cultivars on melanogenesis were investigated in an effort to identify active anti-melanogenesis constituents. The essential oils from the peels of 21 citrus cultivars obtained by hydro-distillation were analyzed using gas chromatography–mass spectrometry. Mouse melanoma B16BL6 cells were used in all assays conducted in this study. The tyrosinase activity and melanin content were determined using the lysate of α-Melanocyte-stimulated B16BL6 cells. In addition, the melanogenic gene expression was determined by quantitative reverse transcription-polymerase chain reaction. Overall, the essential oils of (Citrus unshiu X Citrus sinensis) X Citrus reticulata, Citrus reticulata, and ((Citrus unshiu X Citrus sinensis) X Citrus reticulata) X Citrus reticulata provided the best bioactivity and comprised five distinct constituents compared to other essential oils such as limonene, farnesene, β-elemene, terpinen-4-ol, and sabinene. The anti-melanogenesis activities of the five individual compounds were evaluated. Among the five essential oils, β-elemene, farnesene, and limonene showed dominating properties. The experimental results indicated that (Citrus unshiu X Citrus sinensis) X Citrus reticulata, Citrus reticulata, and ((Citrus unshiu X Citrus sinensis) X Citrus reticulata) X Citrus reticulara are potential candidates with anti-melanogenesis activity for use as cosmetics and pharmaceutical agents against skin hyperpigmentation.

Original languageEnglish
Article number4207
JournalInternational journal of molecular sciences
Volume24
Issue number4
DOIs
Publication statusPublished - 2023 Feb

Bibliographical note

Funding Information:
This was supported by the National Institute of Forest Science (grant number FP0701-2021-01-2023).

Publisher Copyright:
© 2023 by the authors.

Keywords

  • anti-melanogenesis
  • citrus
  • essential oil
  • farnesene
  • limonene
  • natural products
  • β-elemene

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Fingerprint

Dive into the research topics of 'Inhibition of Melanogenesis by Essential Oils from the Citrus Cultivars Peels'. Together they form a unique fingerprint.

Cite this