Inhibition of pathogen adhesion to host cells by polysaccharides from Panax ginseng

Ji Hye Lee; Jin Sun Shim; Mi Sook Chung; Seung Taik Lim; Kyung Hyun Kim

doi:10.1271/bbb.80555

Inhibition of pathogen adhesion to host cells by polysaccharides from Panax ginseng

Ji Hye Lee, Jin Sun Shim, Mi Sook Chung, Seung Taik Lim, Kyung Hyun Kim

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

PG-F2 and PG-HMW from Panax ginseng are pectin-type polysaccharides and PG-HMW might be an arabinogalactan. They demonstrated strong anti-adhesive activities against oral and skin pathogens to host cell lines in a dose-dependent manner from 0.1 to 2.0 mg/ml. While enzymatic hydrolysis caused complete loss of anti-adhesive activities, partial hydrolysis produced oligosaccharides with anti-adhesive properties. PG-F2 and PG-HMW might have a selective anti-adhesive effect against certain pathogenic bacteria without adverse effects on commensal bacteria.

Original language	English
Pages (from-to)	209-212
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	73
Issue number	1
DOIs	https://doi.org/10.1271/bbb.80555
Publication status	Published - 2009

Keywords

Anti-adhesion
Panax ginseng
Pathogenic bacteria
Polysaccharide

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.80555

Cite this

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title = "Inhibition of pathogen adhesion to host cells by polysaccharides from Panax ginseng",

abstract = "PG-F2 and PG-HMW from Panax ginseng are pectin-type polysaccharides and PG-HMW might be an arabinogalactan. They demonstrated strong anti-adhesive activities against oral and skin pathogens to host cell lines in a dose-dependent manner from 0.1 to 2.0 mg/ml. While enzymatic hydrolysis caused complete loss of anti-adhesive activities, partial hydrolysis produced oligosaccharides with anti-adhesive properties. PG-F2 and PG-HMW might have a selective anti-adhesive effect against certain pathogenic bacteria without adverse effects on commensal bacteria.",

keywords = "Anti-adhesion, Panax ginseng, Pathogenic bacteria, Polysaccharide",

author = "Lee, {Ji Hye} and Shim, {Jin Sun} and Chung, {Mi Sook} and Lim, {Seung Taik} and Kim, {Kyung Hyun}",

note = "Funding Information: We wish to thank Mr. K. M. Yeo at S&D Co. for supplying P. ginseng extract samples. This work was supported by a grant from the BioGreen 21 Program (20080401-034-008), the Basic Research Program of the Korea Science & Engineering Foundation, and Korea Research Foundation Grant funded by the Korean Government (KRF-2007-313-C00616).",

year = "2009",

doi = "10.1271/bbb.80555",

language = "English",

volume = "73",

pages = "209--212",

journal = "Bioscience, Biotechnology and Biochemistry",

issn = "0916-8451",

publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",

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T1 - Inhibition of pathogen adhesion to host cells by polysaccharides from Panax ginseng

AU - Lee, Ji Hye

AU - Shim, Jin Sun

AU - Chung, Mi Sook

AU - Lim, Seung Taik

AU - Kim, Kyung Hyun

N1 - Funding Information: We wish to thank Mr. K. M. Yeo at S&D Co. for supplying P. ginseng extract samples. This work was supported by a grant from the BioGreen 21 Program (20080401-034-008), the Basic Research Program of the Korea Science & Engineering Foundation, and Korea Research Foundation Grant funded by the Korean Government (KRF-2007-313-C00616).

PY - 2009

Y1 - 2009

N2 - PG-F2 and PG-HMW from Panax ginseng are pectin-type polysaccharides and PG-HMW might be an arabinogalactan. They demonstrated strong anti-adhesive activities against oral and skin pathogens to host cell lines in a dose-dependent manner from 0.1 to 2.0 mg/ml. While enzymatic hydrolysis caused complete loss of anti-adhesive activities, partial hydrolysis produced oligosaccharides with anti-adhesive properties. PG-F2 and PG-HMW might have a selective anti-adhesive effect against certain pathogenic bacteria without adverse effects on commensal bacteria.

AB - PG-F2 and PG-HMW from Panax ginseng are pectin-type polysaccharides and PG-HMW might be an arabinogalactan. They demonstrated strong anti-adhesive activities against oral and skin pathogens to host cell lines in a dose-dependent manner from 0.1 to 2.0 mg/ml. While enzymatic hydrolysis caused complete loss of anti-adhesive activities, partial hydrolysis produced oligosaccharides with anti-adhesive properties. PG-F2 and PG-HMW might have a selective anti-adhesive effect against certain pathogenic bacteria without adverse effects on commensal bacteria.

KW - Anti-adhesion

KW - Panax ginseng

KW - Pathogenic bacteria

KW - Polysaccharide

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DO - 10.1271/bbb.80555

M3 - Article

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AN - SCOPUS:58849131517

SN - 0916-8451

VL - 73

SP - 209

EP - 212

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 1

ER -

Inhibition of pathogen adhesion to host cells by polysaccharides from Panax ginseng

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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