Inhibition of PTP1B by metabolites from Micromucor ramannianus var. angulisporus CRM000232

Hyuncheol Oh; Beom Seok Kim; Eun Young Bae; Min Soo Kim; Bo Yeon Kim; Hyang Burm Lee; Chang Jin Kim; Jong Seog Ahn

doi:10.7164/antibiotics.57.528

Inhibition of PTP1B by metabolites from Micromucor ramannianus var. angulisporus CRM000232

Hyuncheol Oh
, Beom Seok Kim
, Eun Young Bae
, Min Soo Kim
, Bo Yeon Kim
, Hyang Burm Lee
, Chang Jin Kim
, Jong Seog Ahn^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

In summary, dimeric depside-type fungal matabolite 1, along with biogenetically related compounds 2 and 3, was isolated as a PTP1B inhibitor by bioassay guided fractionation from the EtOAc extract of M. ramannianus var. angulisporus. To our best knowledge, compound 1 is the first PTP1B inhibitor reported from fungal sources, ⁹⁾ and it could serve as a lead compound in design and development of potent PTP-1B inhibitor.

Original language	English
Pages (from-to)	528-531
Number of pages	4
Journal	Journal of Antibiotics
Volume	57
Issue number	8
DOIs	https://doi.org/10.7164/antibiotics.57.528
Publication status	Published - 2004 Aug
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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title = "Inhibition of PTP1B by metabolites from Micromucor ramannianus var. angulisporus CRM000232",

abstract = "In summary, dimeric depside-type fungal matabolite 1, along with biogenetically related compounds 2 and 3, was isolated as a PTP1B inhibitor by bioassay guided fractionation from the EtOAc extract of M. ramannianus var. angulisporus. To our best knowledge, compound 1 is the first PTP1B inhibitor reported from fungal sources, 9) and it could serve as a lead compound in design and development of potent PTP-1B inhibitor.",

author = "Hyuncheol Oh and Kim, \{Beom Seok\} and Bae, \{Eun Young\} and Kim, \{Min Soo\} and Kim, \{Bo Yeon\} and Lee, \{Hyang Burm\} and Kim, \{Chang Jin\} and Ahn, \{Jong Seog\}",

year = "2004",

month = aug,

doi = "10.7164/antibiotics.57.528",

language = "English",

volume = "57",

pages = "528--531",

journal = "Journal of Antibiotics",

issn = "0021-8820",

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T1 - Inhibition of PTP1B by metabolites from Micromucor ramannianus var. angulisporus CRM000232

AU - Oh, Hyuncheol

AU - Kim, Beom Seok

AU - Bae, Eun Young

AU - Kim, Min Soo

AU - Kim, Bo Yeon

AU - Lee, Hyang Burm

AU - Kim, Chang Jin

AU - Ahn, Jong Seog

PY - 2004/8

Y1 - 2004/8

N2 - In summary, dimeric depside-type fungal matabolite 1, along with biogenetically related compounds 2 and 3, was isolated as a PTP1B inhibitor by bioassay guided fractionation from the EtOAc extract of M. ramannianus var. angulisporus. To our best knowledge, compound 1 is the first PTP1B inhibitor reported from fungal sources, 9) and it could serve as a lead compound in design and development of potent PTP-1B inhibitor.

AB - In summary, dimeric depside-type fungal matabolite 1, along with biogenetically related compounds 2 and 3, was isolated as a PTP1B inhibitor by bioassay guided fractionation from the EtOAc extract of M. ramannianus var. angulisporus. To our best knowledge, compound 1 is the first PTP1B inhibitor reported from fungal sources, 9) and it could serve as a lead compound in design and development of potent PTP-1B inhibitor.

UR - https://www.scopus.com/pages/publications/4544383316

U2 - 10.7164/antibiotics.57.528

DO - 10.7164/antibiotics.57.528

M3 - Article

C2 - 15515890

AN - SCOPUS:4544383316

SN - 0021-8820

VL - 57

SP - 528

EP - 531

JO - Journal of Antibiotics

JF - Journal of Antibiotics

IS - 8

ER -

Inhibition of PTP1B by metabolites from Micromucor ramannianus var. angulisporus CRM000232

Abstract

ASJC Scopus subject areas

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