Inhibitory activity of silver nanoparticles synthesized using lycopersicon esculentum against biofilm formation in candida species

Jeong Su Choi, Ji Woong Lee, Un Chul Shin, Min Woo Lee, Dae Jin Kim, Suhng Wook Kim

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


This paper investigated the antifungal and antibiofilm activity of silver nanoparticles synthesized with Lycopersicon esculentum extracts against Candida species. Lycopersicon esculentum extracts obtained by homogenization were mixed with silver nitrate to synthesize silver nanoparticles. Analysis of the particle characteristics by UV-Vis spectrophotometry, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDAX), dynamic light scattering (DLS), and Fourier transform infrared spectroscopy (FT-IR) confirmed that the Lycopersicon esculentum extracts effectively served as reductants and capping agents. Minimum inhibitory concentration (MIC) tests were conducted to confirm antifungal activity against Candida species. In all the tested species, the silver nanoparticles inhibited the growth of Candida. Moreover, the SEM images of Candida species treated with silver nanoparticles synthesized using natural extracts of Lycopersicon esculentum showed that silver nanoparticles adhered to the surface of Candida, which induced pore formation in the membranes and prevented their normal growth. Ultimately, these abnormal forms of Candida were thought to be less able to form biofilms than normal Candida. The antifungal and antibiofilm activities of silver nanoparticles against Candida are expected to be utilized in various fields and contribute in particular to developments in nanomedicine.

Original languageEnglish
Article number1512
Issue number11
Publication statusPublished - 2019 Nov

Bibliographical note

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.


  • Biofilm
  • Candida
  • Lycopersicon esculentum
  • Silver nanoparticles

ASJC Scopus subject areas

  • General Chemical Engineering
  • General Materials Science


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