Inhibitory constituents of Euscaphis japonica on lipopolysaccharide-induced nitric oxide production in BV2 microglia

Kyeong Lee Mi; Young Jeon Hee; Yong Lee Ki; Hyun Kim Seung; Je Ma Choong; Hyun Sung Sang; Heum Sook Lee; Jung Park Mi; Choong Kim Young

doi:10.1055/s-2007-981551

Inhibitory constituents of Euscaphis japonica on lipopolysaccharide-induced nitric oxide production in BV2 microglia

Kyeong Lee Mi
, Young Jeon Hee
, Yong Lee Ki
, Hyun Kim Seung
, Je Ma Choong
, Hyun Sung Sang
, Heum Sook Lee
, Jung Park Mi
, Choong Kim Young^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Bioactivity-guided fractionation of the methanolic extract of the aerial parts of Euscaphis japonica (Tunb.) Kantiz (Staphyleaceae), afforded a new compound, p-coumaroyl-D-malic acid 1-methyl ester (1), together with twelve known compounds, 3,7-dihydro-5-octanolide (2), blumenol A (3), megastigmane (4), gallic acid (5), stenophyllin H1 (6), methyl 5,7-dihydroxyoctanoate (7), frans-phytol (8), α-tocopherol (9), kaempferol (10), kaempferol 3-O-β-D-glucopyranoside (11), quercetin (12) and quercetin 3-O-β-D-glucopyranoside (13). Among them, compounds 1-5 and 8-13 significantly inhibited lipopolysacchride-induced nitric oxide production in murine BV2 microglial cells. Especially, compounds 5,8,10 and 12 exerted potent inhibitory activity comparable to that of NAME, used as positive control.

Original language	English
Pages (from-to)	782-786
Number of pages	5
Journal	Planta Medica
Volume	73
Issue number	8
DOIs	https://doi.org/10.1055/s-2007-981551
Publication status	Published - 2007 Aug
Externally published	Yes

Keywords

Anti-inflammatory
BV2 microglia
Euscaphis japonica
Nitric oxide
p-coumaroyl-D-malic acid 1-methyl ester
Staphyleaceae

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Inhibitory constituents of Euscaphis japonica on lipopolysaccharide-induced nitric oxide production in BV2 microglia",

abstract = "Bioactivity-guided fractionation of the methanolic extract of the aerial parts of Euscaphis japonica (Tunb.) Kantiz (Staphyleaceae), afforded a new compound, p-coumaroyl-D-malic acid 1-methyl ester (1), together with twelve known compounds, 3,7-dihydro-5-octanolide (2), blumenol A (3), megastigmane (4), gallic acid (5), stenophyllin H1 (6), methyl 5,7-dihydroxyoctanoate (7), frans-phytol (8), α-tocopherol (9), kaempferol (10), kaempferol 3-O-β-D-glucopyranoside (11), quercetin (12) and quercetin 3-O-β-D-glucopyranoside (13). Among them, compounds 1-5 and 8-13 significantly inhibited lipopolysacchride-induced nitric oxide production in murine BV2 microglial cells. Especially, compounds 5,8,10 and 12 exerted potent inhibitory activity comparable to that of NAME, used as positive control.",

keywords = "Anti-inflammatory, BV2 microglia, Euscaphis japonica, Nitric oxide, p-coumaroyl-D-malic acid 1-methyl ester, Staphyleaceae",

author = "Mi, \{Kyeong Lee\} and Hee, \{Young Jeon\} and Ki, \{Yong Lee\} and Seung, \{Hyun Kim\} and Choong, \{Je Ma\} and Sang, \{Hyun Sung\} and Lee, \{Heum Sook\} and Mi, \{Jung Park\} and Young, \{Choong Kim\}",

year = "2007",

month = aug,

doi = "10.1055/s-2007-981551",

language = "English",

volume = "73",

pages = "782--786",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

number = "8",

}

TY - JOUR

T1 - Inhibitory constituents of Euscaphis japonica on lipopolysaccharide-induced nitric oxide production in BV2 microglia

AU - Mi, Kyeong Lee

AU - Hee, Young Jeon

AU - Ki, Yong Lee

AU - Seung, Hyun Kim

AU - Choong, Je Ma

AU - Sang, Hyun Sung

AU - Lee, Heum Sook

AU - Mi, Jung Park

AU - Young, Choong Kim

PY - 2007/8

Y1 - 2007/8

N2 - Bioactivity-guided fractionation of the methanolic extract of the aerial parts of Euscaphis japonica (Tunb.) Kantiz (Staphyleaceae), afforded a new compound, p-coumaroyl-D-malic acid 1-methyl ester (1), together with twelve known compounds, 3,7-dihydro-5-octanolide (2), blumenol A (3), megastigmane (4), gallic acid (5), stenophyllin H1 (6), methyl 5,7-dihydroxyoctanoate (7), frans-phytol (8), α-tocopherol (9), kaempferol (10), kaempferol 3-O-β-D-glucopyranoside (11), quercetin (12) and quercetin 3-O-β-D-glucopyranoside (13). Among them, compounds 1-5 and 8-13 significantly inhibited lipopolysacchride-induced nitric oxide production in murine BV2 microglial cells. Especially, compounds 5,8,10 and 12 exerted potent inhibitory activity comparable to that of NAME, used as positive control.

AB - Bioactivity-guided fractionation of the methanolic extract of the aerial parts of Euscaphis japonica (Tunb.) Kantiz (Staphyleaceae), afforded a new compound, p-coumaroyl-D-malic acid 1-methyl ester (1), together with twelve known compounds, 3,7-dihydro-5-octanolide (2), blumenol A (3), megastigmane (4), gallic acid (5), stenophyllin H1 (6), methyl 5,7-dihydroxyoctanoate (7), frans-phytol (8), α-tocopherol (9), kaempferol (10), kaempferol 3-O-β-D-glucopyranoside (11), quercetin (12) and quercetin 3-O-β-D-glucopyranoside (13). Among them, compounds 1-5 and 8-13 significantly inhibited lipopolysacchride-induced nitric oxide production in murine BV2 microglial cells. Especially, compounds 5,8,10 and 12 exerted potent inhibitory activity comparable to that of NAME, used as positive control.

KW - Anti-inflammatory

KW - BV2 microglia

KW - Euscaphis japonica

KW - Nitric oxide

KW - p-coumaroyl-D-malic acid 1-methyl ester

KW - Staphyleaceae

UR - https://www.scopus.com/pages/publications/34547809851

U2 - 10.1055/s-2007-981551

DO - 10.1055/s-2007-981551

M3 - Article

C2 - 17611931

AN - SCOPUS:34547809851

SN - 0032-0943

VL - 73

SP - 782

EP - 786

JO - Planta Medica

JF - Planta Medica

IS - 8

ER -

Inhibitory constituents of Euscaphis japonica on lipopolysaccharide-induced nitric oxide production in BV2 microglia

Abstract

Keywords

ASJC Scopus subject areas

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