Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages

Ji Sang Hwang; Seon A. Lee; Seong Su Hong; Xiang Hua Han; Chul Lee; Dongho Lee; Chong Kil Lee; Jin Tae Hong; Youngsoo Kim; Mi Kyeong Lee; Bang Yeon Hwang

doi:10.1016/j.bmcl.2011.10.043

Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages

Ji Sang Hwang, Seon A. Lee, Seong Su Hong, Xiang Hua Han, Chul Lee, Dongho Lee, Chong Kil Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

The activity-guided fractionation of the MeOH extract of the rhizomes and roots of Nardostachys chinensis led to the isolation of two new sesquiterpenoids, narchinol B (8) and narchinol C (9), along with 10 known compounds, ursolic acid (1), nardosinone (2), pinoresinol (3), desoxo-narchinol A (4), kanshone B (5), epoxyconiferyl alcohol (6), debilon (7), 4α,5-dimethyl-1,3-dioxo-1,2,3,4,4α,5,6,7-octahydronaphthalene (10), p-coumaric acid (11), and isoferulic acid (12). Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. Among the isolates, compounds 2, 4, 5, 8 and 9 showed inhibitory activity against LPS-induced NO production with IC ₅₀ values of 4.6-21.6 μM.

Original language	English
Pages (from-to)	706-708
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	22
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2011.10.043
Publication status	Published - 2012 Jan 1

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MRC, 2010-0029480 ) and a grant from the Korean Ministry of Education, Science and Technology (The Regional Core Research Program/Chungbuk BIT Research-Oriented University Consortium).

Keywords

Nardostachys chinensis
Nitric oxide inhibitor
Sesquiterpenoid
Valerianaceae

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2011.10.043

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abstract = "The activity-guided fractionation of the MeOH extract of the rhizomes and roots of Nardostachys chinensis led to the isolation of two new sesquiterpenoids, narchinol B (8) and narchinol C (9), along with 10 known compounds, ursolic acid (1), nardosinone (2), pinoresinol (3), desoxo-narchinol A (4), kanshone B (5), epoxyconiferyl alcohol (6), debilon (7), 4α,5-dimethyl-1,3-dioxo-1,2,3,4,4α,5,6,7-octahydronaphthalene (10), p-coumaric acid (11), and isoferulic acid (12). Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. Among the isolates, compounds 2, 4, 5, 8 and 9 showed inhibitory activity against LPS-induced NO production with IC 50 values of 4.6-21.6 μM.",

keywords = "Nardostachys chinensis, Nitric oxide inhibitor, Sesquiterpenoid, Valerianaceae",

author = "Hwang, {Ji Sang} and Lee, {Seon A.} and Hong, {Seong Su} and Han, {Xiang Hua} and Chul Lee and Dongho Lee and Lee, {Chong Kil} and Hong, {Jin Tae} and Youngsoo Kim and Lee, {Mi Kyeong} and Hwang, {Bang Yeon}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MRC, 2010-0029480 ) and a grant from the Korean Ministry of Education, Science and Technology (The Regional Core Research Program/Chungbuk BIT Research-Oriented University Consortium).",

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AU - Lee, Chul

AU - Lee, Dongho

AU - Lee, Chong Kil

AU - Hong, Jin Tae

AU - Kim, Youngsoo

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

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PY - 2012/1/1

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Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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