Inhibitory constituents of Sophora tonkinensis on nitric oxide production in RAW 264.7 macrophages

Jin Woo Lee, Ji Hoon Lee, Chul Lee, Qinghao Jin, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


Bioactivity-guided fractionation of the MeOH extract from the roots of Sophora tonkinensis resulted in the isolation of a new pterocarpan glycoside (1) together with nine known compounds, maackiain (2), sophoranone (3), sophoranochromene (4), pinoresinol (5), syringaresinol (6), medioresinol (7), 4′,7-dihydroxyflavone (8), calycosin (9), and genistein (10). The structure of the new compound was determined on the basis of spectroscopic analysis including NMR and CD data in combination with acid hydrolysis. Compounds 1-4 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC50 values ranging from 13.6 to 33.0 μM in RAW 264.7 macrophages.

Original languageEnglish
Pages (from-to)960-962
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number4
Publication statusPublished - 2015 Feb 15

Bibliographical note

Funding Information:
This research was supported financially by the Medical Research Center Program (MRC, 2008-0062275 ) through the National Research Foundation of Korea .

Publisher Copyright:
© 2014 Elsevier Ltd. All rights reserved.


  • Leguminosae
  • Nitric oxide production inhibitor
  • Pterocarpan
  • Sophora tonkinensis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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