Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages

Chul Lee; Jin Woo Lee; Qinghao Jin; Dae Sik Jang; Sung Joon Lee; Dongho Lee; Jin Tae Hong; Youngsoo Kim; Mi Kyeong Lee; Bang Yeon Hwang

doi:10.1016/j.bmcl.2013.04.032

Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages

Chul Lee, Jin Woo Lee, Qinghao Jin, Dae Sik Jang, Sung Joon Lee, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Two new isoflavanones (1 and 13), along with 25 known compounds (2-12, 14-27), were isolated from the EtOAc-soluble fraction of the heartwood of Dalbergia odorifera by following their potential to inhibit the LPS-induced nitric oxide production in RAW 264.7 cells. The structures of the isolated compounds were established by spectroscopic data such as ¹D, ²D NMR and MS spectrometry. Among the isolated compounds, (2S)-pinocembrin (26), showed the most potent inhibitory effect with IC ₅₀ value of 18.1 μM.

Original language	English
Pages (from-to)	4263-4266
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	14
DOIs	https://doi.org/10.1016/j.bmcl.2013.04.032
Publication status	Published - 2013 Jul 15

Bibliographical note

Funding Information:
This work was supported by the Medical Research Center Program ( 2010-0029480 ) through the National Research Foundation of Korea, the Korean Forest Service (Forest Science & Technology Project No. S120912L020120), and the Inter-ER Cooperation Projects (R0002019) through the Ministry of Knowledge Economy (MKE), Korea Institute for Advancement of Technology (KIAT). The authors thank the Center for Research Instruments and Experimental Facilities, Chungbuk National University for providing the NMR spectroscopic measurements.

Keywords

(2S)-Pinocembrin
Dalbergia odorifera
Isoflavonoid
Leguminosae
Nitric oxide

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2013.04.032

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title = "Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages",

abstract = "Two new isoflavanones (1 and 13), along with 25 known compounds (2-12, 14-27), were isolated from the EtOAc-soluble fraction of the heartwood of Dalbergia odorifera by following their potential to inhibit the LPS-induced nitric oxide production in RAW 264.7 cells. The structures of the isolated compounds were established by spectroscopic data such as 1D, 2D NMR and MS spectrometry. Among the isolated compounds, (2S)-pinocembrin (26), showed the most potent inhibitory effect with IC 50 value of 18.1 μM.",

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note = "Funding Information: This work was supported by the Medical Research Center Program ( 2010-0029480 ) through the National Research Foundation of Korea, the Korean Forest Service (Forest Science & Technology Project No. S120912L020120), and the Inter-ER Cooperation Projects (R0002019) through the Ministry of Knowledge Economy (MKE), Korea Institute for Advancement of Technology (KIAT). The authors thank the Center for Research Instruments and Experimental Facilities, Chungbuk National University for providing the NMR spectroscopic measurements. ",

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doi = "10.1016/j.bmcl.2013.04.032",

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AU - Lee, Chul

AU - Lee, Jin Woo

AU - Jin, Qinghao

AU - Jang, Dae Sik

AU - Lee, Sung Joon

AU - Lee, Dongho

AU - Hong, Jin Tae

AU - Kim, Youngsoo

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

N1 - Funding Information: This work was supported by the Medical Research Center Program ( 2010-0029480 ) through the National Research Foundation of Korea, the Korean Forest Service (Forest Science & Technology Project No. S120912L020120), and the Inter-ER Cooperation Projects (R0002019) through the Ministry of Knowledge Economy (MKE), Korea Institute for Advancement of Technology (KIAT). The authors thank the Center for Research Instruments and Experimental Facilities, Chungbuk National University for providing the NMR spectroscopic measurements.

PY - 2013/7/15

Y1 - 2013/7/15

N2 - Two new isoflavanones (1 and 13), along with 25 known compounds (2-12, 14-27), were isolated from the EtOAc-soluble fraction of the heartwood of Dalbergia odorifera by following their potential to inhibit the LPS-induced nitric oxide production in RAW 264.7 cells. The structures of the isolated compounds were established by spectroscopic data such as 1D, 2D NMR and MS spectrometry. Among the isolated compounds, (2S)-pinocembrin (26), showed the most potent inhibitory effect with IC 50 value of 18.1 μM.

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KW - Isoflavonoid

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Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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