Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages

Chul Lee, Jin Woo Lee, Qinghao Jin, Dae Sik Jang, Sung Joon Lee, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


Two new isoflavanones (1 and 13), along with 25 known compounds (2-12, 14-27), were isolated from the EtOAc-soluble fraction of the heartwood of Dalbergia odorifera by following their potential to inhibit the LPS-induced nitric oxide production in RAW 264.7 cells. The structures of the isolated compounds were established by spectroscopic data such as 1D, 2D NMR and MS spectrometry. Among the isolated compounds, (2S)-pinocembrin (26), showed the most potent inhibitory effect with IC 50 value of 18.1 μM.

Original languageEnglish
Pages (from-to)4263-4266
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number14
Publication statusPublished - 2013 Jul 15

Bibliographical note

Funding Information:
This work was supported by the Medical Research Center Program ( 2010-0029480 ) through the National Research Foundation of Korea, the Korean Forest Service (Forest Science & Technology Project No. S120912L020120), and the Inter-ER Cooperation Projects (R0002019) through the Ministry of Knowledge Economy (MKE), Korea Institute for Advancement of Technology (KIAT). The authors thank the Center for Research Instruments and Experimental Facilities, Chungbuk National University for providing the NMR spectroscopic measurements.


  • (2S)-Pinocembrin
  • Dalbergia odorifera
  • Isoflavonoid
  • Leguminosae
  • Nitric oxide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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