Abstract
One of the major sources of air pollution is urban particulate matter (UPM), which causes lung diseases involving oxidative stress, inflammation, and cancer. Codonopsis lanceolata (CL) has been used in East Asia as a traditional oriental medicinal ingredient for lung diseases (e.g., asthma and bronchitis). However, the connection between the impact of CL and UPM in the lungs has rarely been investigated. This study aimed to confirm the inhibitory activity of the ethanol extract of CL (ECL) against oxidative stress and disruption of tight cell junctions in human pulmonary epithelial cells after exposure to UPM. As the lung cells were pre-treated with ECL, the UPM-induced increase in cellular reactive oxygen species production suppressed tight junction proteins (e.g., N-cadherin, fibronectin, occludin, zonula occludens-1, and claudin-4). These results suggest that ECL prevents the possible effects of UPM toxicity on the lungs.
| Original language | English |
|---|---|
| Pages (from-to) | 165-173 |
| Number of pages | 9 |
| Journal | Korean Journal of Food Science and Technology |
| Volume | 53 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2021 Apr |
Bibliographical note
Funding Information:본 연구는 고려대학교 BK21 플러스 생명공학원 사업단의 지 원을 받아 수행되었다(This study was supported by a Korea University Grant and partially supported by School of Life Sciences and Biotechnology of Korea University for BK21 PLUS).
Publisher Copyright:
© The Korean Society of Food Science and Technology
Keywords
- Antioxidant
- Codonopsis lanceolata
- Oxidative stress
- Tight junction
- Urban particulate matter
ASJC Scopus subject areas
- Biotechnology
- Food Science
- Applied Microbiology and Biotechnology
