Inhibitory effect of galactooligosaccharide on skin pigmentation

Min Geun Suh, Yang Hee Hong, Eun Young Jung, Hyung Joo Suh

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


To investigate the effects of ingestion of galactooligosaccharide (GOS) on skin pigmentation, we conducted cell experiments and clinical trials. The effect of GOS on melanin accumulation was assessed in vitro using B16F10 cells. Moreover, melanin and erythema indexes following GOS consumption were explored during a double-blind, randomized, and placebo-controlled study, which included subjects divided by stratified block randomization to placebo or GOS. No cytotoxicity was observed at 70 mg/mL or lower GOS in B16F10 melanoma cells. Melanin accumulation was inhibited at 14 mg/mL or higher GOS. Upon ultraviolet B (UVB) irradiation, the survival of HaCaT cells (control) was reduced to 69.0% lower than baseline. A protective effect of GOS was observed upon treatment with 14∼35 mg/mL GOS; however at 70 mg/mL, cells showed 64% viability compared to control cells irradiated with UVB. Delta values (∆ melanin index), which indicate the difference from the baseline melanin level, were significantly different to placebo (P<0.01) after 8 weeks. In the GOS group, delta values (∆ erythema index), which indicate the difference from baseline erythema level, also significantly differed from the placebo group (P<0.05) after 8 weeks. Our results suggest that intake of prebiotic GOS inhibits skin pigmentation and may represent a novel nutritional approach for skin care.

Original languageEnglish
Pages (from-to)321-326
Number of pages6
JournalPreventive Nutrition and Food Science
Issue number3
Publication statusPublished - 2019


  • B16F10 cells
  • Erythema
  • Galactooligosaccharide
  • Melanin
  • Prebiotic

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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