Inhibitory effect of mulberroside A and its derivatives on melanogenesis induced by ultraviolet B irradiation

Keun Tae Park, Jeong Keun Kim, Dahyun Hwang, Yeongmin Yoo, Young Hee Lim

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)


Mulberroside A was isolated from the ethanol extract of Morus alba roots. The enzymatic hydrolysis of mulberroside A with Pectinex® produced oxyresveratrol and oxyresveratrol-3-O-glucoside. We tested oxyresveratrol, oxyresveratrol-3-O-glucoside, and mulberroside A to determine whether they could inhibit ultraviolet B (UVB) irradiation-induced melanogenesis in brown guinea pig skin. Topical application of mulberroside A, oxyresveratrol, and oxyresveratrol-3-O-glucoside reduced the pigmentation in guinea pig skin. These compounds suppressed the expression of melanogenic enzymes tyrosinase, tyrosinase-related protein-1, and microphthalmia transcription factor. The anti-melanogenesis effect was highest with oxyresveratrol, intermediate with oxyresveratrol-3-O-glucoside, and lowest with mulberroside A. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosylation of mulberroside A resulted in enhanced inhibition of melanogenesis. Histological analysis with Fontana-Masson staining confirmed that these compounds significantly reduced the melanin content in the epidermis of UVB-irradiated guinea pig skin compared to the vehicle control. Thus, these compounds effectively reduced pigmentation and may be suitable cosmetic agents for skin whitening.

Original languageEnglish
Pages (from-to)3038-3045
Number of pages8
JournalFood and Chemical Toxicology
Issue number12
Publication statusPublished - 2011 Dec


  • Guinea pig
  • Melanogenesis inhibition
  • Mulberroside A
  • Oxyresveratrol
  • Tyrosinase inhibition

ASJC Scopus subject areas

  • Food Science
  • Toxicology


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