Inhibitory effect on NO production of phenolic compounds from Myristica fragrans

To Dao Cuong; Tran Manh Hung; Minkyun Na; Do Thi Ha; Jin Cheol Kim; Dongho Lee; Sungwoo Ryoo; Jeong Hyung Lee; Jae Sue Choi; Byung Sun Min

doi:10.1016/j.bmcl.2011.09.021

Inhibitory effect on NO production of phenolic compounds from Myristica fragrans

To Dao Cuong, Tran Manh Hung, Minkyun Na, Do Thi Ha, Jin Cheol Kim, Dongho Lee, Sungwoo Ryoo, Jeong Hyung Lee, Jae Sue Choi, Byung Sun Min

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Three new phenolics: ((7S)-8′-(benzo[3′,4′]dioxol- 1′-yl)-7-hydroxypropyl)benzene-2,4-diol (1), ((7S)-8′-(4′- hydroxy-3′-methoxyphenyl)-7-hydroxypropyl)benzene-2,4-diol (2) and ((8R,8′S)-7-(4-hydroxy-3-methoxyphenyl)-8′-methylbutan-8-yl) -3′-methoxybenzene-4′,5′-diol (3), along with four known compounds (4-7) were isolated from the seeds of Myristica fragrans. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against LPS-induced NO production in macrophage RAW264.7 cells.

Original language	English
Pages (from-to)	6884-6887
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	22
DOIs	https://doi.org/10.1016/j.bmcl.2011.09.021
Publication status	Published - 2011 Nov 15

Bibliographical note

Funding Information:
This research was supported by the National Research Foundation of Korea Grant funded by the Korean Government (MEST) ( KRF-2009-0084675 ).

Keywords

Anti-inflammatory activity
Myristica fragrans
Myristicaceae
Phenolic

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2011.09.021

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title = "Inhibitory effect on NO production of phenolic compounds from Myristica fragrans",

abstract = "Three new phenolics: ((7S)-8′-(benzo[3′,4′]dioxol- 1′-yl)-7-hydroxypropyl)benzene-2,4-diol (1), ((7S)-8′-(4′- hydroxy-3′-methoxyphenyl)-7-hydroxypropyl)benzene-2,4-diol (2) and ((8R,8′S)-7-(4-hydroxy-3-methoxyphenyl)-8′-methylbutan-8-yl) -3′-methoxybenzene-4′,5′-diol (3), along with four known compounds (4-7) were isolated from the seeds of Myristica fragrans. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against LPS-induced NO production in macrophage RAW264.7 cells.",

keywords = "Anti-inflammatory activity, Myristica fragrans, Myristicaceae, Phenolic",

author = "Cuong, {To Dao} and Hung, {Tran Manh} and Minkyun Na and Ha, {Do Thi} and Kim, {Jin Cheol} and Dongho Lee and Sungwoo Ryoo and Lee, {Jeong Hyung} and Choi, {Jae Sue} and Min, {Byung Sun}",

note = "Funding Information: This research was supported by the National Research Foundation of Korea Grant funded by the Korean Government (MEST) ( KRF-2009-0084675 ). ",

year = "2011",

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doi = "10.1016/j.bmcl.2011.09.021",

language = "English",

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AU - Cuong, To Dao

AU - Hung, Tran Manh

AU - Na, Minkyun

AU - Ha, Do Thi

AU - Kim, Jin Cheol

AU - Lee, Dongho

AU - Ryoo, Sungwoo

AU - Lee, Jeong Hyung

AU - Choi, Jae Sue

AU - Min, Byung Sun

N1 - Funding Information: This research was supported by the National Research Foundation of Korea Grant funded by the Korean Government (MEST) ( KRF-2009-0084675 ).

PY - 2011/11/15

Y1 - 2011/11/15

N2 - Three new phenolics: ((7S)-8′-(benzo[3′,4′]dioxol- 1′-yl)-7-hydroxypropyl)benzene-2,4-diol (1), ((7S)-8′-(4′- hydroxy-3′-methoxyphenyl)-7-hydroxypropyl)benzene-2,4-diol (2) and ((8R,8′S)-7-(4-hydroxy-3-methoxyphenyl)-8′-methylbutan-8-yl) -3′-methoxybenzene-4′,5′-diol (3), along with four known compounds (4-7) were isolated from the seeds of Myristica fragrans. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against LPS-induced NO production in macrophage RAW264.7 cells.

AB - Three new phenolics: ((7S)-8′-(benzo[3′,4′]dioxol- 1′-yl)-7-hydroxypropyl)benzene-2,4-diol (1), ((7S)-8′-(4′- hydroxy-3′-methoxyphenyl)-7-hydroxypropyl)benzene-2,4-diol (2) and ((8R,8′S)-7-(4-hydroxy-3-methoxyphenyl)-8′-methylbutan-8-yl) -3′-methoxybenzene-4′,5′-diol (3), along with four known compounds (4-7) were isolated from the seeds of Myristica fragrans. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against LPS-induced NO production in macrophage RAW264.7 cells.

KW - Anti-inflammatory activity

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KW - Myristicaceae

KW - Phenolic

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ER -

Inhibitory effect on NO production of phenolic compounds from Myristica fragrans

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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