Inhibitory Effects of Pterocarpus santalinus Extract against IgE/Antigen-Sensitized Mast Cells and Atopic Dermatitis-Like Skin Lesions

Baknoon Ham, Myungsuk Kim, Yang Ju Son, Sungyul Chang, Sang Hoon Jung, Chu Won Nho, Man Jae Kwon

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12 Citations (Scopus)


Pterocarpus santalinus has been traditionally used as a medicinal plant owing to its anti-inflammatory, anthelmintic, tonic, antihyperglycemic, and diaphoretic properties. We hypothesized that P. santalinus might have therapeutic potential in alleviating allergy and atopic dermatitis. Thus, we investigated the inhibitory effects of P. santalinus extract against allergic responses and 2,4-dinitrochlorobenzene-induced atopic dermatitis-like dorsal skin lesions using immunoglobulin E-sensitized rat basophilic leukemia-2H3 mast cells and NC/Nga mice. Degranulation and enzyme-linked immunosorbent assays were conducted to measure degranulation, proinflammatory cytokine levels, and prostaglandin E 2 concentrations in immunoglobulin E/antigen-sensitized RBL-2H3 mast cells. The therapeutic efficacy of P. santalinus extract in 2,4-dinitrochlorobenzene-induced atopic dermatitis was evaluated through morphological, physiological, and immunological analysis. P. santalinus extract inhibited β -hexosaminidase and histamine release and reduced tumor necrosis factor- α, interleukin-4, and prostaglandin E 2 secretion. Furthermore, P. santalinus extract suppressed atopic dermatitis-like skin lesions by regulating the serum levels of immunoglobulin E and immunoglobulin G2a, and messenger ribonucleic acid expression of T helper cell 1- and T helper cell 2-related mediators in the skin lesions. Histopathological analyses showed a decrease in epidermal thickness and intradermal inflammatory cell infiltration. These results suggested that P. santalinus extract might have beneficial effects in treating allergic and atopic dermatitis-like skin disorders.

Original languageEnglish
Pages (from-to)599-607
Number of pages9
JournalPlanta Medica
Issue number7
Publication statusPublished - 2019

Bibliographical note

Funding Information:
This work was supported by the KIST Gangneung Institute (2Z04690). B.H. was partially supported by a National Research Foundation of Korea Grant funded by the Korean Government (MEST) (2017, University-Institute Cooperation Program).

Publisher Copyright:
© Georg Thieme Verlag KG Stuttgart New York.


  • IgE
  • Leguminosae
  • Pterocarpus santalinus
  • RBL-2H3 mast cell
  • Th1/Th2-related mediators
  • atopic dermatitis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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