Initial experience in hybrid PET-MRI for evaluation of refractory focal onset epilepsy

Hae W. Shin, Valerie Jewells, Arif Sheikh, Jingwen Zhang, Hongtu Zhu, Hongyu An, Wei Gao, Dinggang Shen, Eldad Hadar, Weili Lin

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


Purpose We aim to evaluate the utility/improved accuracy of hybrid PET/MR compared to current practice separate 3 T MRI and PET-CT imaging for localization of seizure foci. Method In a pilot study, twenty-nine patients undergoing epilepsy surgery evaluation were imaged using PET/MR. This subject group had 29 previous clinical 3 T MRI as well as 12 PET-CT studies. Prior clinical PET and MR images were read sequentially while the hybrid PET/MR was concurrently read. Results The median interval between hybrid PET/MR and prior imaging studies was 5 months (range 1-77 months). In 24 patients, there was no change in the read between the clinical exams and hybrid PET/MR while new anatomical or functional lesions were identified by hybrid PET/MR in 5 patients without significant clinical change. Four new anatomical MR lesions were seen with concordant PET findings. The remaining patient revealed a new abnormal PET lesion without an MR abnormality. All new PET/MR lesions were clinically significant with concordant EEG and/or SPECT results as potential epileptic foci. Conclusion Our initial hybrid PET-MRI experience increased diagnostic yields for detection of potential epileptic lesions. This may be due to the unique advantage of improved co-registration and simultaneous review of both structural and functional data.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
Publication statusPublished - 2015 Sept 1

Bibliographical note

Publisher Copyright:
© 2015 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.


  • 3 T MRI and PET-CT
  • Epilepsy
  • Epilepsy surgery evaluation
  • Hybrid PET-MRI

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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