Purpose We aim to evaluate the utility/improved accuracy of hybrid PET/MR compared to current practice separate 3 T MRI and PET-CT imaging for localization of seizure foci. Method In a pilot study, twenty-nine patients undergoing epilepsy surgery evaluation were imaged using PET/MR. This subject group had 29 previous clinical 3 T MRI as well as 12 PET-CT studies. Prior clinical PET and MR images were read sequentially while the hybrid PET/MR was concurrently read. Results The median interval between hybrid PET/MR and prior imaging studies was 5 months (range 1-77 months). In 24 patients, there was no change in the read between the clinical exams and hybrid PET/MR while new anatomical or functional lesions were identified by hybrid PET/MR in 5 patients without significant clinical change. Four new anatomical MR lesions were seen with concordant PET findings. The remaining patient revealed a new abnormal PET lesion without an MR abnormality. All new PET/MR lesions were clinically significant with concordant EEG and/or SPECT results as potential epileptic foci. Conclusion Our initial hybrid PET-MRI experience increased diagnostic yields for detection of potential epileptic lesions. This may be due to the unique advantage of improved co-registration and simultaneous review of both structural and functional data.
Bibliographical notePublisher Copyright:
© 2015 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
- 3 T MRI and PET-CT
- Epilepsy surgery evaluation
- Hybrid PET-MRI
ASJC Scopus subject areas
- Clinical Neurology