Injectable hydrogel harnessing foreskin mesenchymal stem cell-derived extracellular vesicles for treatment of chronic diabetic skin wounds

Chang Xu, Jin Feng Cao, Yue Pei, Yujin Kim, Huiyeon Moon, Chui Qin Fan, Mao Chuan Liao, Xing Yu Wang, Fei Yao, Yu Jun Zhang, Shao Hui Zhang, Jian Zhang, Jian Zhang Li, Jong Seung Kim, Lian Ma, Zhong Jian Xie

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic skin wounds are a serious complication of diabetes with a high incidence rate, which can lead to disability or even death. Previous studies have shown that mesenchymal stem cells derived extracellular vesicles (EVs) have beneficial effects on wound healing. However, the human foreskin mesenchymal stem cell (FSMSCs)-derived extracellular vesicle (FM-EV) has not yet been isolated and characterized. Furthermore, the limited supply and short lifespan of EVs also hinder their practical use. In this study, we developed an injectable dual-physical cross-linking hydrogel (PSiW) with self-healing, adhesive, and antibacterial properties, using polyvinylpyrrolidone and silicotungstic acid to load FM-EV. The EVs were evenly distributed in the hydrogel and continuously released. In vivo and vitro tests demonstrated that the synergistic effect of EVs and hydrogel could significantly promote the repair of diabetic wounds by regulating macrophage polarization, promoting angiogenesis, and improving the microenvironment. Overall, the obtained EVs-loaded hydrogels developed in this work exhibited promising applicability for the repair of chronic skin wounds in diabetes patients.

Original languageEnglish
Pages (from-to)339-353
Number of pages15
JournalJournal of Controlled Release
Volume370
DOIs
Publication statusPublished - 2024 Jun

Bibliographical note

Publisher Copyright:
© 2024

Keywords

  • Diabetic wound healing
  • Extracellular vesicles
  • Foreskin-derived mesenchymal stem cells
  • Hydrogel
  • Multifunctional wound dressing

ASJC Scopus subject areas

  • Pharmaceutical Science

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