Innate and adaptive functions of the CD1 pathway of antigen presentation

Se Ho Park; Ya Hui Chiu; Jayanthi Jayawardena; Jessica Roark; Uma Kavita; Albert Bendelac

doi:10.1006/smim.1998.0139

Innate and adaptive functions of the CD1 pathway of antigen presentation

Se Ho Park, Ya Hui Chiu, Jayanthi Jayawardena, Jessica Roark, Uma Kavita, Albert Bendelac

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

In the past few years, several studies have unravelled a novel pathway of antigen presentation to T cells of the mammalian immune system. The antigens are presented by CD1, which appears to have evolved to present glycolipid antigens to αβ T cells. CD1-restricted T cells are frequently autoreactive, and can promptly release key regulatory cytokines such as IL-4 and IFN-γ. They have been implicated in a variety of autoimmune diseases including type I diabetes and lupus, in intracellular bacterial infections, and in tumor rejection. They are likely to be involved at the early, innate phase of these immune responses, providing a unique model to study the interface between the innate and adaptive immune systems.

Original language	English
Pages (from-to)	391-398
Number of pages	8
Journal	Seminars in Immunology
Volume	10
Issue number	5
DOIs	https://doi.org/10.1006/smim.1998.0139
Publication status	Published - 1998 Oct
Externally published	Yes

Keywords

CD1
Glycolipids
Innate immunity
Interleukin-4
T cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1006/smim.1998.0139

Cite this

@article{fdf19a51728646e583c874c75ebf22a5,

title = "Innate and adaptive functions of the CD1 pathway of antigen presentation",

abstract = "In the past few years, several studies have unravelled a novel pathway of antigen presentation to T cells of the mammalian immune system. The antigens are presented by CD1, which appears to have evolved to present glycolipid antigens to αβ T cells. CD1-restricted T cells are frequently autoreactive, and can promptly release key regulatory cytokines such as IL-4 and IFN-γ. They have been implicated in a variety of autoimmune diseases including type I diabetes and lupus, in intracellular bacterial infections, and in tumor rejection. They are likely to be involved at the early, innate phase of these immune responses, providing a unique model to study the interface between the innate and adaptive immune systems.",

keywords = "CD1, Glycolipids, Innate immunity, Interleukin-4, T cells",

author = "Park, {Se Ho} and Chiu, {Ya Hui} and Jayanthi Jayawardena and Jessica Roark and Uma Kavita and Albert Bendelac",

note = "Funding Information: The authors wish to thank Claude Carnaud and Polly Matzinger for discussions, suggestions, and for reviewing the manuscript. We thank M. Corr, S. Joyce, S. Porcelli and I. Wilson for sharing data prior to publication. Research in our laboratory is supported by grants form National Institutes of Health AI38339, American Cancer Society IM 788, Juvenile Diabetes Foundation, Mallinckrodt Foundation, a Cancer Research Institute Investigator Award (A.B.), a Juvenile Diabetes Foundation Fellowship (J.H.R.).",

year = "1998",

month = oct,

doi = "10.1006/smim.1998.0139",

language = "English",

volume = "10",

pages = "391--398",

journal = "Seminars in Immunology",

issn = "1044-5323",

publisher = "Academic Press Inc.",

number = "5",

}

TY - JOUR

T1 - Innate and adaptive functions of the CD1 pathway of antigen presentation

AU - Park, Se Ho

AU - Chiu, Ya Hui

AU - Jayawardena, Jayanthi

AU - Roark, Jessica

AU - Kavita, Uma

AU - Bendelac, Albert

N1 - Funding Information: The authors wish to thank Claude Carnaud and Polly Matzinger for discussions, suggestions, and for reviewing the manuscript. We thank M. Corr, S. Joyce, S. Porcelli and I. Wilson for sharing data prior to publication. Research in our laboratory is supported by grants form National Institutes of Health AI38339, American Cancer Society IM 788, Juvenile Diabetes Foundation, Mallinckrodt Foundation, a Cancer Research Institute Investigator Award (A.B.), a Juvenile Diabetes Foundation Fellowship (J.H.R.).

PY - 1998/10

Y1 - 1998/10

N2 - In the past few years, several studies have unravelled a novel pathway of antigen presentation to T cells of the mammalian immune system. The antigens are presented by CD1, which appears to have evolved to present glycolipid antigens to αβ T cells. CD1-restricted T cells are frequently autoreactive, and can promptly release key regulatory cytokines such as IL-4 and IFN-γ. They have been implicated in a variety of autoimmune diseases including type I diabetes and lupus, in intracellular bacterial infections, and in tumor rejection. They are likely to be involved at the early, innate phase of these immune responses, providing a unique model to study the interface between the innate and adaptive immune systems.

AB - In the past few years, several studies have unravelled a novel pathway of antigen presentation to T cells of the mammalian immune system. The antigens are presented by CD1, which appears to have evolved to present glycolipid antigens to αβ T cells. CD1-restricted T cells are frequently autoreactive, and can promptly release key regulatory cytokines such as IL-4 and IFN-γ. They have been implicated in a variety of autoimmune diseases including type I diabetes and lupus, in intracellular bacterial infections, and in tumor rejection. They are likely to be involved at the early, innate phase of these immune responses, providing a unique model to study the interface between the innate and adaptive immune systems.

KW - CD1

KW - Glycolipids

KW - Innate immunity

KW - Interleukin-4

KW - T cells

UR - http://www.scopus.com/inward/record.url?scp=0032191191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032191191&partnerID=8YFLogxK

U2 - 10.1006/smim.1998.0139

DO - 10.1006/smim.1998.0139

M3 - Article

C2 - 9799714

AN - SCOPUS:0032191191

SN - 1044-5323

VL - 10

SP - 391

EP - 398

JO - Seminars in Immunology

JF - Seminars in Immunology

IS - 5

ER -

Innate and adaptive functions of the CD1 pathway of antigen presentation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this