Abstract
In the past few years, several studies have unravelled a novel pathway of antigen presentation to T cells of the mammalian immune system. The antigens are presented by CD1, which appears to have evolved to present glycolipid antigens to αβ T cells. CD1-restricted T cells are frequently autoreactive, and can promptly release key regulatory cytokines such as IL-4 and IFN-γ. They have been implicated in a variety of autoimmune diseases including type I diabetes and lupus, in intracellular bacterial infections, and in tumor rejection. They are likely to be involved at the early, innate phase of these immune responses, providing a unique model to study the interface between the innate and adaptive immune systems.
Original language | English |
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Pages (from-to) | 391-398 |
Number of pages | 8 |
Journal | Seminars in Immunology |
Volume | 10 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1998 Oct |
Externally published | Yes |
Keywords
- CD1
- Glycolipids
- Innate immunity
- Interleukin-4
- T cells
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology