Abstract
In the past few years, several studies have unravelled a novel pathway of antigen presentation to T cells of the mammalian immune system. The antigens are presented by CD1, which appears to have evolved to present glycolipid antigens to αβ T cells. CD1-restricted T cells are frequently autoreactive, and can promptly release key regulatory cytokines such as IL-4 and IFN-γ. They have been implicated in a variety of autoimmune diseases including type I diabetes and lupus, in intracellular bacterial infections, and in tumor rejection. They are likely to be involved at the early, innate phase of these immune responses, providing a unique model to study the interface between the innate and adaptive immune systems.
| Original language | English |
|---|---|
| Pages (from-to) | 391-398 |
| Number of pages | 8 |
| Journal | Seminars in Immunology |
| Volume | 10 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1998 Oct |
| Externally published | Yes |
Bibliographical note
Funding Information:The authors wish to thank Claude Carnaud and Polly Matzinger for discussions, suggestions, and for reviewing the manuscript. We thank M. Corr, S. Joyce, S. Porcelli and I. Wilson for sharing data prior to publication. Research in our laboratory is supported by grants form National Institutes of Health AI38339, American Cancer Society IM 788, Juvenile Diabetes Foundation, Mallinckrodt Foundation, a Cancer Research Institute Investigator Award (A.B.), a Juvenile Diabetes Foundation Fellowship (J.H.R.).
Keywords
- CD1
- Glycolipids
- Innate immunity
- Interleukin-4
- T cells
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
