Innate immune stimulation of exo-polymers prepared from Cordyceps sinensis by submerged culture

Taek Joon Yoon; Kwang Won Yu; Kwang Soon Shin; Hyung Joo Suh

doi:10.1007/s00253-008-1607-y

Innate immune stimulation of exo-polymers prepared from Cordyceps sinensis by submerged culture

Taek Joon Yoon, Kwang Won Yu, Kwang Soon Shin, Hyung Joo Suh

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

After we prepared exo-polymers (EPS) from Cordyceps sinensis by submerged culture, prophylactic intravenous administration (i.v.) of EPS significantly inhibited metastasis in experimental lung metastasis of colon 26-M3.1 carcinoma. Cytotoxicity against Yac-1 tumor cells of natural killer (NK) cell, which was prepared by i.v. of EPS (100 μg/mouse), significantly augmented 2 days after EPS treatment. When NK cells were depleted by rabbit anti-asialo GM1 serum, even the EPS group totally abolished the inhibitory effect on lung metastasis of colon 26-M3.1 cells. EPS can stimulate innate immune system to inhibit tumor metastasis, and its anti-tumor metastasis is associated with macrophage and NK cell activation.

Original language	English
Pages (from-to)	1087-1093
Number of pages	7
Journal	Applied Microbiology and Biotechnology
Volume	80
Issue number	6
DOIs	https://doi.org/10.1007/s00253-008-1607-y
Publication status	Published - 2008 Oct

Bibliographical note

Funding Information:
Acknowledgment This study was carried out with the support of “On-Site Cooperative Agriculture Research Project (Project No. 20070401080069)”, RDA, Republic of Korea.

Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.

Keywords

Cordyceps sinensis
Cytokine
Exo-polymer
Innate immunity
NK cell
Tumor metastasis

ASJC Scopus subject areas

Biotechnology
Applied Microbiology and Biotechnology

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10.1007/s00253-008-1607-y

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title = "Innate immune stimulation of exo-polymers prepared from Cordyceps sinensis by submerged culture",

abstract = "After we prepared exo-polymers (EPS) from Cordyceps sinensis by submerged culture, prophylactic intravenous administration (i.v.) of EPS significantly inhibited metastasis in experimental lung metastasis of colon 26-M3.1 carcinoma. Cytotoxicity against Yac-1 tumor cells of natural killer (NK) cell, which was prepared by i.v. of EPS (100 μg/mouse), significantly augmented 2 days after EPS treatment. When NK cells were depleted by rabbit anti-asialo GM1 serum, even the EPS group totally abolished the inhibitory effect on lung metastasis of colon 26-M3.1 cells. EPS can stimulate innate immune system to inhibit tumor metastasis, and its anti-tumor metastasis is associated with macrophage and NK cell activation.",

keywords = "Cordyceps sinensis, Cytokine, Exo-polymer, Innate immunity, NK cell, Tumor metastasis",

author = "Yoon, {Taek Joon} and Yu, {Kwang Won} and Shin, {Kwang Soon} and Suh, {Hyung Joo}",

note = "Funding Information: Acknowledgment This study was carried out with the support of “On-Site Cooperative Agriculture Research Project (Project No. 20070401080069)”, RDA, Republic of Korea. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",

year = "2008",

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doi = "10.1007/s00253-008-1607-y",

language = "English",

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AU - Yoon, Taek Joon

AU - Yu, Kwang Won

AU - Shin, Kwang Soon

AU - Suh, Hyung Joo

N1 - Funding Information: Acknowledgment This study was carried out with the support of “On-Site Cooperative Agriculture Research Project (Project No. 20070401080069)”, RDA, Republic of Korea. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.

PY - 2008/10

Y1 - 2008/10

N2 - After we prepared exo-polymers (EPS) from Cordyceps sinensis by submerged culture, prophylactic intravenous administration (i.v.) of EPS significantly inhibited metastasis in experimental lung metastasis of colon 26-M3.1 carcinoma. Cytotoxicity against Yac-1 tumor cells of natural killer (NK) cell, which was prepared by i.v. of EPS (100 μg/mouse), significantly augmented 2 days after EPS treatment. When NK cells were depleted by rabbit anti-asialo GM1 serum, even the EPS group totally abolished the inhibitory effect on lung metastasis of colon 26-M3.1 cells. EPS can stimulate innate immune system to inhibit tumor metastasis, and its anti-tumor metastasis is associated with macrophage and NK cell activation.

AB - After we prepared exo-polymers (EPS) from Cordyceps sinensis by submerged culture, prophylactic intravenous administration (i.v.) of EPS significantly inhibited metastasis in experimental lung metastasis of colon 26-M3.1 carcinoma. Cytotoxicity against Yac-1 tumor cells of natural killer (NK) cell, which was prepared by i.v. of EPS (100 μg/mouse), significantly augmented 2 days after EPS treatment. When NK cells were depleted by rabbit anti-asialo GM1 serum, even the EPS group totally abolished the inhibitory effect on lung metastasis of colon 26-M3.1 cells. EPS can stimulate innate immune system to inhibit tumor metastasis, and its anti-tumor metastasis is associated with macrophage and NK cell activation.

KW - Cordyceps sinensis

KW - Cytokine

KW - Exo-polymer

KW - Innate immunity

KW - NK cell

KW - Tumor metastasis

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JO - Applied Microbiology and Biotechnology

JF - Applied Microbiology and Biotechnology

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ER -

Innate immune stimulation of exo-polymers prepared from Cordyceps sinensis by submerged culture

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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