Recently, nanotechnology has provided significant advances in biomedical applications including diagnosis and therapy. In particular, nanoparticles have emerged as valuable outcomes of nanotechnology due to their unique physicochemical properties based on size, shape, and surface properties. Among them, a large amount of research has reported imaging and therapeutic applications using inorganic nanoparticles with special properties. Inorganic nanoparticles developed for imaging and therapy contain metal (Au), metal oxide (Fe3O4, WO3, WO2.9), semiconductor nanocrystal (quantum dots (QDs)), and lanthanide-doped upconversion nanoparticles (UCNPs). Based on their intrinsic properties, they can generate heat, reactive oxygen species (ROS), or energy transfer, so that they can be used for both imaging and therapy. In this review, we introduce biocompatible inorganic nanoparticles for image-guided thermal and photodynamic therapy, and discuss their promising results from in vitro and in vivo studies for biomedical applications.
Bibliographical noteFunding Information:
This work was supported by the GRL project (NRF-2013K1A1A2A02050115), High Medical Technology Project (HI14C2755) of KHIDI, the Intramural Research Program (CATS) of KIST, Basic Science Research Program by the Ministry of Education (2016R1C1B3013951) through the National Research Foundation of Korea, and the financial support of the Catholic Medical Center Research Foundation made in the program year of 2016.
© 2016 American Chemical Society.
ASJC Scopus subject areas
- Biomedical Engineering
- Pharmaceutical Science
- Organic Chemistry