Insights into characterization methods and biomedical applications of nanoparticle-protein corona

Yan Li; Jae Seung Lee

doi:10.3390/ma13143093

Insights into characterization methods and biomedical applications of nanoparticle-protein corona

Yan Li, Jae Seung Lee

Research output: Contribution to journal › Review article › peer-review

33 Citations (Scopus)

Abstract

Nanoparticles (NPs) exposed to a biological milieu will strongly interact with proteins, forming "coronas" on the surfaces of the NPs. The protein coronas (PCs) affect the properties of the NPs and provide a new biological identity to the particles in the biological environment. The characterization of NP-PC complexes has attracted enormous research attention, owing to the crucial effects of the properties of an NP-PC on its interactions with living systems, as well as the diverse applications of NP-PC complexes. The analysis of NP-PC complexes without a well-considered approach will inevitably lead to misunderstandings and inappropriate applications of NPs. This review introduces methods for the characterization of NP-PC complexes and investigates their recent applications in biomedicine. Furthermore, the review evaluates these characterization methods based on comprehensive critical views and provides future perspectives regarding the applications of NP-PC complexes.

Original language	English
Article number	3093
Journal	Materials
Volume	13
Issue number	14
DOIs	https://doi.org/10.3390/ma13143093
Publication status	Published - 2020 Jul

Bibliographical note

Publisher Copyright:
© 2020 by the authors.

Keywords

Biomedical application
Characterization
Nanoparticles
Protein corona

ASJC Scopus subject areas

General Materials Science

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10.3390/ma13143093

Cite this

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abstract = "Nanoparticles (NPs) exposed to a biological milieu will strongly interact with proteins, forming {"}coronas{"} on the surfaces of the NPs. The protein coronas (PCs) affect the properties of the NPs and provide a new biological identity to the particles in the biological environment. The characterization of NP-PC complexes has attracted enormous research attention, owing to the crucial effects of the properties of an NP-PC on its interactions with living systems, as well as the diverse applications of NP-PC complexes. The analysis of NP-PC complexes without a well-considered approach will inevitably lead to misunderstandings and inappropriate applications of NPs. This review introduces methods for the characterization of NP-PC complexes and investigates their recent applications in biomedicine. Furthermore, the review evaluates these characterization methods based on comprehensive critical views and provides future perspectives regarding the applications of NP-PC complexes.",

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AU - Lee, Jae Seung

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AB - Nanoparticles (NPs) exposed to a biological milieu will strongly interact with proteins, forming "coronas" on the surfaces of the NPs. The protein coronas (PCs) affect the properties of the NPs and provide a new biological identity to the particles in the biological environment. The characterization of NP-PC complexes has attracted enormous research attention, owing to the crucial effects of the properties of an NP-PC on its interactions with living systems, as well as the diverse applications of NP-PC complexes. The analysis of NP-PC complexes without a well-considered approach will inevitably lead to misunderstandings and inappropriate applications of NPs. This review introduces methods for the characterization of NP-PC complexes and investigates their recent applications in biomedicine. Furthermore, the review evaluates these characterization methods based on comprehensive critical views and provides future perspectives regarding the applications of NP-PC complexes.

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Insights into characterization methods and biomedical applications of nanoparticle-protein corona

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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