Instructive Effect of Visual Experience in Mouse Visual Cortex

Mikhail Y. Frenkel; Nathaniel B. Sawtell; Antonia Cinira M. Diogo; Bongjune Yoon; Rachael L. Neve; Mark F. Bear

doi:10.1016/j.neuron.2006.06.026

Instructive Effect of Visual Experience in Mouse Visual Cortex

Mikhail Y. Frenkel, Nathaniel B. Sawtell, Antonia Cinira M. Diogo, Bongjune Yoon, Rachael L. Neve, Mark F. Bear

Research output: Contribution to journal › Article › peer-review

208 Citations (Scopus)

Abstract

We describe a form of experience-dependent response enhancement in the visual cortex of awake mice. Repeated presentations of grating stimuli of a single orientation result in a persistent enhancement of responses evoked by the test stimulus. Response potentiation is specific to the orientation of the test stimulus, develops gradually over the course of several training sessions, and occurs in both juvenile and adult mice. The stimulus-selective response potentiation (SRP) can mask deprivation-induced response depression in adult mice. SRP requires NMDA receptor activation and is prevented by viral delivery of a peptide that interferes with AMPA receptor trafficking. SRP may reveal the mechanisms involved in certain forms of perceptual learning.

Original language	English
Pages (from-to)	339-349
Number of pages	11
Journal	Neuron
Volume	51
Issue number	3
DOIs	https://doi.org/10.1016/j.neuron.2006.06.026
Publication status	Published - 2006 Aug 3
Externally published	Yes

Keywords

SYSNEURO

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neuron.2006.06.026

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abstract = "We describe a form of experience-dependent response enhancement in the visual cortex of awake mice. Repeated presentations of grating stimuli of a single orientation result in a persistent enhancement of responses evoked by the test stimulus. Response potentiation is specific to the orientation of the test stimulus, develops gradually over the course of several training sessions, and occurs in both juvenile and adult mice. The stimulus-selective response potentiation (SRP) can mask deprivation-induced response depression in adult mice. SRP requires NMDA receptor activation and is prevented by viral delivery of a peptide that interferes with AMPA receptor trafficking. SRP may reveal the mechanisms involved in certain forms of perceptual learning.",

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author = "Frenkel, {Mikhail Y.} and Sawtell, {Nathaniel B.} and Diogo, {Antonia Cinira M.} and Bongjune Yoon and Neve, {Rachael L.} and Bear, {Mark F.}",

note = "Funding Information: We thank Dr. Barry Connors, Dr. Michael Paradiso, Dr. Wolf Singer, and Dr. Arnold Heynen for helpful discussions, Dr. Marshall Shuler for his help with single-unit recordings, and Erik Sklar and Suzanne Meagher for their help with this manuscript. This work was supported in part by the Howard Hughes Medical Institute and a grant from the National Eye Institute. A.C.M.D. is supported by PRONEX/FAPERJ.",

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doi = "10.1016/j.neuron.2006.06.026",

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AU - Sawtell, Nathaniel B.

AU - Diogo, Antonia Cinira M.

AU - Yoon, Bongjune

AU - Neve, Rachael L.

AU - Bear, Mark F.

N1 - Funding Information: We thank Dr. Barry Connors, Dr. Michael Paradiso, Dr. Wolf Singer, and Dr. Arnold Heynen for helpful discussions, Dr. Marshall Shuler for his help with single-unit recordings, and Erik Sklar and Suzanne Meagher for their help with this manuscript. This work was supported in part by the Howard Hughes Medical Institute and a grant from the National Eye Institute. A.C.M.D. is supported by PRONEX/FAPERJ.

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Y1 - 2006/8/3

N2 - We describe a form of experience-dependent response enhancement in the visual cortex of awake mice. Repeated presentations of grating stimuli of a single orientation result in a persistent enhancement of responses evoked by the test stimulus. Response potentiation is specific to the orientation of the test stimulus, develops gradually over the course of several training sessions, and occurs in both juvenile and adult mice. The stimulus-selective response potentiation (SRP) can mask deprivation-induced response depression in adult mice. SRP requires NMDA receptor activation and is prevented by viral delivery of a peptide that interferes with AMPA receptor trafficking. SRP may reveal the mechanisms involved in certain forms of perceptual learning.

AB - We describe a form of experience-dependent response enhancement in the visual cortex of awake mice. Repeated presentations of grating stimuli of a single orientation result in a persistent enhancement of responses evoked by the test stimulus. Response potentiation is specific to the orientation of the test stimulus, develops gradually over the course of several training sessions, and occurs in both juvenile and adult mice. The stimulus-selective response potentiation (SRP) can mask deprivation-induced response depression in adult mice. SRP requires NMDA receptor activation and is prevented by viral delivery of a peptide that interferes with AMPA receptor trafficking. SRP may reveal the mechanisms involved in certain forms of perceptual learning.

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Instructive Effect of Visual Experience in Mouse Visual Cortex

Abstract

Keywords

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