Instrumentation for Time-of-Flight Positron Emission Tomography

Muhammad Nasir Ullah; Eva Pratiwi; Jimin Cheon; Hojong Choi; Jung Yeol Yeom

doi:10.1007/s13139-016-0401-5

Instrumentation for Time-of-Flight Positron Emission Tomography

Muhammad Nasir Ullah, Eva Pratiwi, Jimin Cheon, Hojong Choi, Jung Yeol Yeom

School of Biomedical Engineering

Research output: Contribution to journal › Review article › peer-review

27 Citations (Scopus)

Abstract

Positron emission tomography (PET) is a molecular imaging modality that provides information at the molecular level. This system is composed of radiation detectors to detect incoming coincident annihilation gamma photons emitted from the radiopharmaceutical injected into a patient’s body and uses these data to reconstruct images. A major trend in PET instrumentation is the development of time-of-flight positron emission tomography (ToF-PET). In ToF-PET, the time information (the instant the radiation is detected) is incorporated for image reconstruction. Therefore, precise and accurate timing recording is crucial in ToF-PET. ToF-PET leads to better localization of the annihilation event and thus results in overall improvement in the signal-to-noise ratio (SNR) of the reconstructed image. Several factors affect the timing performance of ToF-PET. In this article, the background, early research and recent advances in ToF-PET instrumentation are presented. Emphasis is placed on the various types of scintillators, photodetectors and electronic circuitry for use in ToF-PET, and their impact on timing resolution is discussed.

Original language	English
Pages (from-to)	112-122
Number of pages	11
Journal	Nuclear Medicine and Molecular Imaging
Volume	50
Issue number	2
DOIs	https://doi.org/10.1007/s13139-016-0401-5
Publication status	Published - 2016 Jun 1

Bibliographical note

Funding Information:
This work is supported in part by the National Research Foundation of Korea (NRF-2014R1A1A1005242), MSIP (Ministry of Science, ICT and Future Planning), Korea, under the C-ITRC (Convergence Information Technology Research Center) (IITP-2015-H8601-15-1011) supervised by the IITP (Institute for Information & Communications Technology Promotion) and Quality of Working Life (QWL) (N0000842) Program funded by the Ministry of Trade, Industry & Energy of Korea.

Publisher Copyright:
© 2016, Korean Society of Nuclear Medicine.

Keywords

Instrumentation
Positron emission tomography
Time of flight
Timing resolution

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1007/s13139-016-0401-5

Cite this

@article{4b90be89c05f47c1a32bd5f2b8b6f907,

title = "Instrumentation for Time-of-Flight Positron Emission Tomography",

abstract = "Positron emission tomography (PET) is a molecular imaging modality that provides information at the molecular level. This system is composed of radiation detectors to detect incoming coincident annihilation gamma photons emitted from the radiopharmaceutical injected into a patient{\textquoteright}s body and uses these data to reconstruct images. A major trend in PET instrumentation is the development of time-of-flight positron emission tomography (ToF-PET). In ToF-PET, the time information (the instant the radiation is detected) is incorporated for image reconstruction. Therefore, precise and accurate timing recording is crucial in ToF-PET. ToF-PET leads to better localization of the annihilation event and thus results in overall improvement in the signal-to-noise ratio (SNR) of the reconstructed image. Several factors affect the timing performance of ToF-PET. In this article, the background, early research and recent advances in ToF-PET instrumentation are presented. Emphasis is placed on the various types of scintillators, photodetectors and electronic circuitry for use in ToF-PET, and their impact on timing resolution is discussed.",

keywords = "Instrumentation, Positron emission tomography, Time of flight, Timing resolution",

author = "Ullah, {Muhammad Nasir} and Eva Pratiwi and Jimin Cheon and Hojong Choi and Yeom, {Jung Yeol}",

note = "Funding Information: This work is supported in part by the National Research Foundation of Korea (NRF-2014R1A1A1005242), MSIP (Ministry of Science, ICT and Future Planning), Korea, under the C-ITRC (Convergence Information Technology Research Center) (IITP-2015-H8601-15-1011) supervised by the IITP (Institute for Information & Communications Technology Promotion) and Quality of Working Life (QWL) (N0000842) Program funded by the Ministry of Trade, Industry & Energy of Korea. Publisher Copyright: {\textcopyright} 2016, Korean Society of Nuclear Medicine.",

year = "2016",

month = jun,

day = "1",

doi = "10.1007/s13139-016-0401-5",

language = "English",

volume = "50",

pages = "112--122",

journal = "Nuclear Medicine and Molecular Imaging",

issn = "1869-3474",

publisher = "Springer Verlag",

number = "2",

}

TY - JOUR

T1 - Instrumentation for Time-of-Flight Positron Emission Tomography

AU - Ullah, Muhammad Nasir

AU - Pratiwi, Eva

AU - Cheon, Jimin

AU - Choi, Hojong

AU - Yeom, Jung Yeol

N1 - Funding Information: This work is supported in part by the National Research Foundation of Korea (NRF-2014R1A1A1005242), MSIP (Ministry of Science, ICT and Future Planning), Korea, under the C-ITRC (Convergence Information Technology Research Center) (IITP-2015-H8601-15-1011) supervised by the IITP (Institute for Information & Communications Technology Promotion) and Quality of Working Life (QWL) (N0000842) Program funded by the Ministry of Trade, Industry & Energy of Korea. Publisher Copyright: © 2016, Korean Society of Nuclear Medicine.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Positron emission tomography (PET) is a molecular imaging modality that provides information at the molecular level. This system is composed of radiation detectors to detect incoming coincident annihilation gamma photons emitted from the radiopharmaceutical injected into a patient’s body and uses these data to reconstruct images. A major trend in PET instrumentation is the development of time-of-flight positron emission tomography (ToF-PET). In ToF-PET, the time information (the instant the radiation is detected) is incorporated for image reconstruction. Therefore, precise and accurate timing recording is crucial in ToF-PET. ToF-PET leads to better localization of the annihilation event and thus results in overall improvement in the signal-to-noise ratio (SNR) of the reconstructed image. Several factors affect the timing performance of ToF-PET. In this article, the background, early research and recent advances in ToF-PET instrumentation are presented. Emphasis is placed on the various types of scintillators, photodetectors and electronic circuitry for use in ToF-PET, and their impact on timing resolution is discussed.

AB - Positron emission tomography (PET) is a molecular imaging modality that provides information at the molecular level. This system is composed of radiation detectors to detect incoming coincident annihilation gamma photons emitted from the radiopharmaceutical injected into a patient’s body and uses these data to reconstruct images. A major trend in PET instrumentation is the development of time-of-flight positron emission tomography (ToF-PET). In ToF-PET, the time information (the instant the radiation is detected) is incorporated for image reconstruction. Therefore, precise and accurate timing recording is crucial in ToF-PET. ToF-PET leads to better localization of the annihilation event and thus results in overall improvement in the signal-to-noise ratio (SNR) of the reconstructed image. Several factors affect the timing performance of ToF-PET. In this article, the background, early research and recent advances in ToF-PET instrumentation are presented. Emphasis is placed on the various types of scintillators, photodetectors and electronic circuitry for use in ToF-PET, and their impact on timing resolution is discussed.

KW - Instrumentation

KW - Positron emission tomography

KW - Time of flight

KW - Timing resolution

UR - http://www.scopus.com/inward/record.url?scp=84969972597&partnerID=8YFLogxK

U2 - 10.1007/s13139-016-0401-5

DO - 10.1007/s13139-016-0401-5

M3 - Review article

AN - SCOPUS:84969972597

SN - 1869-3474

VL - 50

SP - 112

EP - 122

JO - Nuclear Medicine and Molecular Imaging

JF - Nuclear Medicine and Molecular Imaging

IS - 2

ER -

Instrumentation for Time-of-Flight Positron Emission Tomography

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this