Positron emission tomography (PET) is a molecular imaging modality that provides information at the molecular level. This system is composed of radiation detectors to detect incoming coincident annihilation gamma photons emitted from the radiopharmaceutical injected into a patient’s body and uses these data to reconstruct images. A major trend in PET instrumentation is the development of time-of-flight positron emission tomography (ToF-PET). In ToF-PET, the time information (the instant the radiation is detected) is incorporated for image reconstruction. Therefore, precise and accurate timing recording is crucial in ToF-PET. ToF-PET leads to better localization of the annihilation event and thus results in overall improvement in the signal-to-noise ratio (SNR) of the reconstructed image. Several factors affect the timing performance of ToF-PET. In this article, the background, early research and recent advances in ToF-PET instrumentation are presented. Emphasis is placed on the various types of scintillators, photodetectors and electronic circuitry for use in ToF-PET, and their impact on timing resolution is discussed.
Bibliographical noteFunding Information:
This work is supported in part by the National Research Foundation of Korea (NRF-2014R1A1A1005242), MSIP (Ministry of Science, ICT and Future Planning), Korea, under the C-ITRC (Convergence Information Technology Research Center) (IITP-2015-H8601-15-1011) supervised by the IITP (Institute for Information & Communications Technology Promotion) and Quality of Working Life (QWL) (N0000842) Program funded by the Ministry of Trade, Industry & Energy of Korea.
© 2016, Korean Society of Nuclear Medicine.
- Positron emission tomography
- Time of flight
- Timing resolution
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging