Integrated photonic structures for parallel fluorescence and refractive index biosensing

Meredith M. Lee, Thomas D. O'Sullivan, Antonio Cerruto, Victor Liu, Jingyu Zhang, Ofer Levi, Heon Lee, Steven R.J. Brueck, Shanhui Fan, James S. Harris

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)


We present a multi-modality optical sensing platform employing integrated Vertical Cavity Surface Emitting Lasers (VCSELs), photodetectors, and filters suitable for portable, real-time analyte detection in aqueous environments. Fluorescence and refractive index sensors designed to utilize visible and near-infrared VCSELs for low background absorption from analyte delivery fluids are described. We demonstrate in vitro fluorescence sensing of Cy5.5 dye with a detection sensitivity of 5 nM and photonic crystal slab refractive index sensing with tunable GaAs-based 670 nm VCSELs. This compact, parallel sensor architecture enables multiplexed, cost-effective on-chip biosensing.

Original languageEnglish
Title of host publicationPhotonic Microdevices/Microstructures for Sensing III
Publication statusPublished - 2011
EventPhotonic Microdevices/Microstructures for Sensing III - Orlando, FL, United States
Duration: 2011 Apr 272011 Apr 28

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


OtherPhotonic Microdevices/Microstructures for Sensing III
Country/TerritoryUnited States
CityOrlando, FL


  • Biosensing
  • Fluorescence
  • Integrated
  • Lab-on-a-chip
  • Label free
  • Photonic crystal
  • Sensor

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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