Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation

Do Yeun Park, Jaeseo Lee, Justin J. Chung, Youngmee Jung, Soo Hyun Kim

Research output: Contribution to journalReview articlepeer-review

60 Citations (Scopus)


Organs-on-chips (OoCs) have attracted significant attention because they can be designed to mimic in vivo environments. Beyond constructing a single OoC, recent efforts have tried to integrate multiple OoCs to broaden potential applications such as disease modeling and drug discoveries. However, various challenges remain for integrating OoCs towards in vivo-like operation, such as incorporating various connections for integrating multiple OoCs. We review multiplexed OoCs and challenges they face: scaling, vascularization, and innervation. In our opinion, future OoCs will be constructed to have increased predictive power for in vivo phenomena and will ultimately become a mainstream tool for high quality biomedical and pharmaceutical research.

Original languageEnglish
Pages (from-to)99-112
Number of pages14
JournalTrends in Biotechnology
Issue number1
Publication statusPublished - 2020 Jan

Bibliographical note

Funding Information:
This work was supported by the Korea University (KU) and the Korea Institute of Science and Technology (KIST) (KU-KIST) Graduate School of Converging Science and Technology Program, by a grant from the Global Ph.D. Fellowship Program of the National Research Foundation, Republic of Korea (2015H1A2A1033269), and by the KIST Institutional Program.

Publisher Copyright:
© 2019 Elsevier Ltd


  • innervation-on-a-chip
  • integrated organ-on-a-chip
  • multiplexing
  • organ-on-chip
  • scaling rules
  • vascularization-on-a-chip

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering


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