Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation

Do Yeun Park; Jaeseo Lee; Justin J. Chung; Youngmee Jung; Soo Hyun Kim

doi:10.1016/j.tibtech.2019.06.006

Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation

Do Yeun Park
, Jaeseo Lee
, Justin J. Chung
, Youngmee Jung
, Soo Hyun Kim^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

92 Citations (Scopus)

Abstract

Organs-on-chips (OoCs) have attracted significant attention because they can be designed to mimic in vivo environments. Beyond constructing a single OoC, recent efforts have tried to integrate multiple OoCs to broaden potential applications such as disease modeling and drug discoveries. However, various challenges remain for integrating OoCs towards in vivo-like operation, such as incorporating various connections for integrating multiple OoCs. We review multiplexed OoCs and challenges they face: scaling, vascularization, and innervation. In our opinion, future OoCs will be constructed to have increased predictive power for in vivo phenomena and will ultimately become a mainstream tool for high quality biomedical and pharmaceutical research.

Original language	English
Pages (from-to)	99-112
Number of pages	14
Journal	Trends in Biotechnology
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/j.tibtech.2019.06.006
Publication status	Published - 2020 Jan

Bibliographical note

Funding Information:
This work was supported by the Korea University (KU) and the Korea Institute of Science and Technology (KIST) (KU-KIST) Graduate School of Converging Science and Technology Program, by a grant from the Global Ph.D. Fellowship Program of the National Research Foundation, Republic of Korea (2015H1A2A1033269), and by the KIST Institutional Program.

Publisher Copyright:
© 2019 Elsevier Ltd

Keywords

innervation-on-a-chip
integrated organ-on-a-chip
multiplexing
organ-on-chip
scaling rules
vascularization-on-a-chip

ASJC Scopus subject areas

Biotechnology
Bioengineering

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10.1016/j.tibtech.2019.06.006

Cite this

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title = "Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation",

abstract = "Organs-on-chips (OoCs) have attracted significant attention because they can be designed to mimic in vivo environments. Beyond constructing a single OoC, recent efforts have tried to integrate multiple OoCs to broaden potential applications such as disease modeling and drug discoveries. However, various challenges remain for integrating OoCs towards in vivo-like operation, such as incorporating various connections for integrating multiple OoCs. We review multiplexed OoCs and challenges they face: scaling, vascularization, and innervation. In our opinion, future OoCs will be constructed to have increased predictive power for in vivo phenomena and will ultimately become a mainstream tool for high quality biomedical and pharmaceutical research.",

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author = "Park, \{Do Yeun\} and Jaeseo Lee and Chung, \{Justin J.\} and Youngmee Jung and Kim, \{Soo Hyun\}",

note = "Funding Information: This work was supported by the Korea University (KU) and the Korea Institute of Science and Technology (KIST) (KU-KIST) Graduate School of Converging Science and Technology Program, by a grant from the Global Ph.D. Fellowship Program of the National Research Foundation, Republic of Korea (2015H1A2A1033269), and by the KIST Institutional Program. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2020",

month = jan,

doi = "10.1016/j.tibtech.2019.06.006",

language = "English",

volume = "38",

pages = "99--112",

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AU - Park, Do Yeun

AU - Lee, Jaeseo

AU - Chung, Justin J.

AU - Jung, Youngmee

AU - Kim, Soo Hyun

N1 - Funding Information: This work was supported by the Korea University (KU) and the Korea Institute of Science and Technology (KIST) (KU-KIST) Graduate School of Converging Science and Technology Program, by a grant from the Global Ph.D. Fellowship Program of the National Research Foundation, Republic of Korea (2015H1A2A1033269), and by the KIST Institutional Program. Publisher Copyright: © 2019 Elsevier Ltd

PY - 2020/1

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AB - Organs-on-chips (OoCs) have attracted significant attention because they can be designed to mimic in vivo environments. Beyond constructing a single OoC, recent efforts have tried to integrate multiple OoCs to broaden potential applications such as disease modeling and drug discoveries. However, various challenges remain for integrating OoCs towards in vivo-like operation, such as incorporating various connections for integrating multiple OoCs. We review multiplexed OoCs and challenges they face: scaling, vascularization, and innervation. In our opinion, future OoCs will be constructed to have increased predictive power for in vivo phenomena and will ultimately become a mainstream tool for high quality biomedical and pharmaceutical research.

KW - innervation-on-a-chip

KW - integrated organ-on-a-chip

KW - multiplexing

KW - organ-on-chip

KW - scaling rules

KW - vascularization-on-a-chip

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DO - 10.1016/j.tibtech.2019.06.006

M3 - Review article

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SN - 0167-7799

VL - 38

SP - 99

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JF - Trends in Biotechnology

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ER -

Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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