Integration of Brassinosteroid Signal Transduction with the Transcription Network for Plant Growth Regulation in Arabidopsis

Yu Sun; Xi Ying Fan; Dong Mei Cao; Wenqiang Tang; Kun He; Jia Ying Zhu; Jun Xian He; Ming Yi Bai; Shengwei Zhu; Eunkyoo Oh; Sunita Patil; Tae Wuk Kim; Hongkai Ji; Wing Hong Wong; Seung Y. Rhee; Zhi Yong Wang

doi:10.1016/j.devcel.2010.10.010

Integration of Brassinosteroid Signal Transduction with the Transcription Network for Plant Growth Regulation in Arabidopsis

Yu Sun, Xi Ying Fan, Dong Mei Cao, Wenqiang Tang, Kun He, Jia Ying Zhu, Jun Xian He, Ming Yi Bai, Shengwei Zhu, Eunkyoo Oh, Sunita Patil, Tae Wuk Kim, Hongkai Ji, Wing Hong Wong, Seung Y. Rhee, Zhi Yong Wang

Research output: Contribution to journal › Article › peer-review

750 Citations (Scopus)

Abstract

Brassinosteroids (BRs) regulate a wide range of developmental and physiological processes in plants through a receptor-kinase signaling pathway that controls the BZR transcription factors. Here, we use transcript profiling and chromatin-immunoprecipitation microarray (ChIP-chip) experiments to identify 953 BR-regulated BZR1 target (BRBT) genes. Functional studies of selected BRBTs further demonstrate roles in BR promotion of cell elongation. The BRBT genes reveal numerous molecular links between the BR-signaling pathway and downstream components involved in developmental and physiological processes. Furthermore, the results reveal extensive crosstalk between BR and other hormonal and light-signaling pathways at multiple levels. For example, BZR1 not only controls the expression of many signaling components of other hormonal and light pathways but also coregulates common target genes with light-signaling transcription factors. Our results provide a genomic map of steroid hormone actions in plants that reveals a regulatory network that integrates hormonal and light-signaling pathways for plant growth regulation.

Original language	English
Pages (from-to)	765-777
Number of pages	13
Journal	Developmental Cell
Volume	19
Issue number	5
DOIs	https://doi.org/10.1016/j.devcel.2010.10.010
Publication status	Published - 2010 Nov 16
Externally published	Yes

Bibliographical note

Funding Information:
We thank Dr. Shauna Somerville and Bi-Huei Hou for technical assistance in microarray analyses and Dr. Peter Quail for providing the anti-PHYB antibody. This study was supported by grants from NIH (R01GM066258) and NSFC (30470169). S.Z. was supported by the Chinese Scholarship Council.

ASJC Scopus subject areas

Molecular Biology
General Biochemistry,Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2010.10.010

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Sun, Y., Fan, X. Y., Cao, D. M., Tang, W., He, K., Zhu, J. Y., He, J. X., Bai, M. Y., Zhu, S., Oh, E., Patil, S., Kim, T. W., Ji, H., Wong, W. H., Rhee, S. Y., & Wang, Z. Y. (2010). Integration of Brassinosteroid Signal Transduction with the Transcription Network for Plant Growth Regulation in Arabidopsis. Developmental Cell, 19(5), 765-777. https://doi.org/10.1016/j.devcel.2010.10.010

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abstract = "Brassinosteroids (BRs) regulate a wide range of developmental and physiological processes in plants through a receptor-kinase signaling pathway that controls the BZR transcription factors. Here, we use transcript profiling and chromatin-immunoprecipitation microarray (ChIP-chip) experiments to identify 953 BR-regulated BZR1 target (BRBT) genes. Functional studies of selected BRBTs further demonstrate roles in BR promotion of cell elongation. The BRBT genes reveal numerous molecular links between the BR-signaling pathway and downstream components involved in developmental and physiological processes. Furthermore, the results reveal extensive crosstalk between BR and other hormonal and light-signaling pathways at multiple levels. For example, BZR1 not only controls the expression of many signaling components of other hormonal and light pathways but also coregulates common target genes with light-signaling transcription factors. Our results provide a genomic map of steroid hormone actions in plants that reveals a regulatory network that integrates hormonal and light-signaling pathways for plant growth regulation.",

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AU - Zhu, Jia Ying

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PY - 2010/11/16

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N2 - Brassinosteroids (BRs) regulate a wide range of developmental and physiological processes in plants through a receptor-kinase signaling pathway that controls the BZR transcription factors. Here, we use transcript profiling and chromatin-immunoprecipitation microarray (ChIP-chip) experiments to identify 953 BR-regulated BZR1 target (BRBT) genes. Functional studies of selected BRBTs further demonstrate roles in BR promotion of cell elongation. The BRBT genes reveal numerous molecular links between the BR-signaling pathway and downstream components involved in developmental and physiological processes. Furthermore, the results reveal extensive crosstalk between BR and other hormonal and light-signaling pathways at multiple levels. For example, BZR1 not only controls the expression of many signaling components of other hormonal and light pathways but also coregulates common target genes with light-signaling transcription factors. Our results provide a genomic map of steroid hormone actions in plants that reveals a regulatory network that integrates hormonal and light-signaling pathways for plant growth regulation.

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Integration of Brassinosteroid Signal Transduction with the Transcription Network for Plant Growth Regulation in Arabidopsis

Abstract

Bibliographical note

ASJC Scopus subject areas

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