Integration of temporal and spatial properties of dynamic connectivity networks for automatic diagnosis of brain disease

Biao Jie, Mingxia Liu, Dinggang Shen

Research output: Contribution to journalArticlepeer-review

116 Citations (Scopus)

Abstract

Functional connectivity networks (FCNs) using resting-state functional magnetic resonance imaging (rs-fMRI) have been applied to the analysis and diagnosis of brain disease, such as Alzheimer's disease (AD) and its prodrome, i.e., mild cognitive impairment (MCI). Different from conventional studies focusing on static descriptions on functional connectivity (FC) between brain regions in rs-fMRI, recent studies have resorted to dynamic connectivity networks (DCNs) to characterize the dynamic changes of FC, since dynamic changes of FC may indicate changes in macroscopic neural activity patterns in cognitive and behavioral aspects. However, most of the existing studies only investigate the temporal properties of DCNs (e.g., temporal variability of FC between specific brain regions), ignoring the important spatial properties of the network (e.g., spatial variability of FC associated with a specific brain region). Also, emerging evidence on FCNs has suggested that, besides temporal variability, there is significant spatial variability of activity foci over time. Hence, integrating both temporal and spatial properties of DCNs can intuitively promote the performance of connectivity-network-based learning methods. In this paper, we first define a new measure to characterize the spatial variability of DCNs, and then propose a novel learning framework to integrate both temporal and spatial variabilities of DCNs for automatic brain disease diagnosis. Specifically, we first construct DCNs from the rs-fMRI time series at successive non-overlapping time windows. Then, we characterize the spatial variability of a specific brain region by computing the correlation of functional sequences (i.e., the changing profile of FC between a pair of brain regions within all time windows) associated with this region. Furthermore, we extract both temporal variabilities and spatial variabilities from DCNs as features, and integrate them for classification by using manifold regularized multi-task feature learning and multi-kernel learning techniques. Results on 149 subjects with baseline rs-fMRI data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) suggest that our method can not only improve the classification performance in comparison with state-of-the-art methods, but also provide insights into the spatio-temporal interaction patterns of brain activity and their changes in brain disorders.

Original languageEnglish
Pages (from-to)81-94
Number of pages14
JournalMedical Image Analysis
Volume47
DOIs
Publication statusPublished - 2018 Jul

Bibliographical note

Funding Information:
This study was supported by National Natural Science Foundation of China ( 61573023 , 61703301 , 61602072 ), NIH grants ( EB006733 , EB008374 , EB022880 , AG041721 , AG042599 ), Foundation for Outstanding Young in Higher Education of Anhui , China ( gxyqZD2017010 ) and AHNU-DRSF ( 2016XJJ120 ).

Funding Information:
Data collection and sharing for this project was funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) National Institutes of Health Grant U01 AG024904. ADNI is funded by the National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: Abbott, AstraZeneca AB, Amorfix, Bayer Schering Pharma AG, Bioclinica Inc., Biogen Idec, Bristol- Myers Squibb, Eisai Global Clinical Development, Elan Corporation, Genentech, GE Healthcare, Innogenetics, IXICO, Janssen Alzheimer Immunotherapy, Johnson and Johnson, Eli Lilly and Co., Medpace, Inc., Merck and Co., Inc., Meso Scale Diagnostic, & LLC, Novartis AG, Pfizer Inc, F. Hoffman-La Roche, Servier, Synarc, Inc., and Takeda Pharmaceuticals, as well as non-profit partners the Alzheimer's Association and Alzheimer's Drug Discovery Foundation, with participation from the U.S. Food and Drug Administration. Private sector contributions to ADNI are facilitated by the Foundation for the National Institutes of Health (www.fnih.org). The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer's Disease Cooperative Study at the University of California, San Diego. ADNI data are disseminated by the Laboratory for Neuro Imaging at the University of California, Los Angeles.

Publisher Copyright:
© 2018 Elsevier B.V.

Keywords

  • Alzheimer's disease
  • Classification
  • Functional connectivity network
  • Spatial variability
  • Temporal variability

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Computer Vision and Pattern Recognition
  • Health Informatics
  • Computer Graphics and Computer-Aided Design

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