Integrative analysis of brain region-specific Shank3 interactomes for understanding the heterogeneity of neuronal pathophysiology related to SHANK3 mutations

Keyphrases

• Brain Regions 100%
• Pathophysiology 100%
• Interactome 100%
• SHANK3 100%
• Integrative Analysis 100%
• Medial Prefrontal Cortex (mPFC) 35%
• Striatal 35%
• Protein Complex 11%
• Scaffold Protein 11%
• Neuropsychiatric Disorders 11%
• Neurodevelopmental Disorders 11%
• Phenotypic Diversity 11%
• Risk Genes 11%
• Biological Function 5%
• Point mutation 5%
• Molecular Genetic Testing 5%
• Postsynaptic Density Protein 95 (PSD-95) 5%
• Schizophrenia 5%
• Bioinformatics 5%
• Deletion mutation 5%
• Proteome 5%
• Path Analysis 5%
• Bipolar Disorder 5%
• Attention Deficit Hyperactivity Disorder 5%
• Intellectual Disability 5%
• Postsynapse 5%
• Duplication mutation 5%
• Hybrid Optimization Model for Electric Renewables (HOMER) 5%
• Autism Spectrum Disorder 5%
• Interconnected Networks 5%
• Differential Protein Expression Profiles 5%
• SAPAP 5%

Neuroscience

• Prefrontal Cortex 100%
• Protein Complexes 33%
• Scaffold Protein 33%
• Neurodevelopmental Disorder 33%
• In Vivo 16%
• Synapse 16%
• Point Mutation 16%
• Protein Expression 16%
• Postsynaptic Density 16%
• Pervasive Developmental Disorder 16%
• Bipolar Disorder 16%
• Attention Deficit Hyperactivity Disorder 16%
• SAP90/PSD95 Associated Protein 16%

Biochemistry, Genetics and Molecular Biology

• Interactome 100%
• SHANK3 100%
• Protein Complexes 22%
• Scaffold Protein 22%
• Proteome 11%
• Molecular Genetics 11%
• Synapse 11%
• Point Mutation 11%
• Biological Functions 11%
• Protein Expression 11%
• Postsynaptic Density 11%
• Intellectual Disability 11%