Integrative analysis of multi-dimensional imaging genomics data for alzheimer's disease prediction

The Alzheimer’S Disease Neuroimaging Initiative

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


In this paper, we explore the effects of integrating multi-dimensional imaging genomics data for Alzheimer's disease (AD) prediction using machine learning approaches. Precisely, we compare our three recent proposed feature selection methods (i.e. multiple kernel learning (MKL), high order graph matching based feature selection (HGM-FS), sparse multimodal learning (SMML)) using four widely-used modalities (i.e. magnetic resonance imaging (MRI), positron emission tomography (PET), cerebrospinal fluid (CSF), and genetic modality single-nucleotide polymor phism (SNP)). This study demonstrates the performance of each method using these modalities individually or integratively, and may be valuable to clinical tests in practice. Our experimental results suggest that for AD prediction, in general, (1) in terms of accuracy, PET is the best modality; (2) Even though the discriminant power of genetic SNP features is weak, adding this modality to other modalities does help improve the classification accuracy; (3) HGM-FS works best among the three feature selection methods; (4) Some of the selected features are shared by all the feature selection methods, which may have high correlation with the disease. Using all the modalities on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset, the best accuracies, described as (mean±standard deviation)%, among the three methods are (76.2±11.3)% for AD vs. MCI, (94.8±7.3)% for AD vs. HC, (76.5±11.1)% for MCI vs. HC, and (71.0±8.4)% for AD vs. MCI vs. HC, respectively.

Original languageEnglish
Article number260
JournalFrontiers in Aging Neuroscience
Issue numberSEP
Publication statusPublished - 2014


  • Alzheimer's disease prediction
  • Binary and multiclass classification
  • Feature selection
  • Imaging genomics data
  • Modality integration

ASJC Scopus subject areas

  • Ageing
  • Cognitive Neuroscience


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