Intense accumulation of 18F-FDG, not enhancement on MRI, helps to guide the surgical biopsy accurately in soft tissue tumors

Jong Hoon Park; Eun Kyung Park; Chang Ho Kang; Chul Hwan Kim; Jae Gol Choe; Won Noh

doi:10.1007/s12149-009-0313-x

Intense accumulation of ¹⁸F-FDG, not enhancement on MRI, helps to guide the surgical biopsy accurately in soft tissue tumors

Jong Hoon Park, Eun Kyung Park, Chang Ho Kang, Chul Hwan Kim, Jae Gol Choe, Won Noh

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Soft tissue sarcomas are a highly heterogeneous group of malignancies that arise from mesenchymal tissues. Grading of soft tissue sarcomas is an important prerequisite for the choice of therapy and estimation of prognosis. However, incisional biopsy of huge soft tissue sarcoma lesions frequently fails to provide an accurate diagnosis when there is a benign component, cystic changes and/or necrosis. MRI is helpful in evaluating the extent of the sarcoma lesion, vascularization, invasiveness and integrity of surrounding tissue, but definitive differentiation of benignity and malignancy is not possible with it. In this study, positron emission tomography using [¹⁸F]-2-fluoro-2- deoxy-d-glucose successfully guided surgeons to identify the most hypermetabolic and, therefore, the most suitable biopsy sites of huge soft tissue sarcoma.

Original language	English
Pages (from-to)	887-889
Number of pages	3
Journal	Annals of Nuclear Medicine
Volume	23
Issue number	10
DOIs	https://doi.org/10.1007/s12149-009-0313-x
Publication status	Published - 2009 Dec

Keywords

FDG PET
MR
Metabolic biopsy
Sarcoma
Soft tissue tumor

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1007/s12149-009-0313-x

Cite this

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title = "Intense accumulation of 18F-FDG, not enhancement on MRI, helps to guide the surgical biopsy accurately in soft tissue tumors",

abstract = "Soft tissue sarcomas are a highly heterogeneous group of malignancies that arise from mesenchymal tissues. Grading of soft tissue sarcomas is an important prerequisite for the choice of therapy and estimation of prognosis. However, incisional biopsy of huge soft tissue sarcoma lesions frequently fails to provide an accurate diagnosis when there is a benign component, cystic changes and/or necrosis. MRI is helpful in evaluating the extent of the sarcoma lesion, vascularization, invasiveness and integrity of surrounding tissue, but definitive differentiation of benignity and malignancy is not possible with it. In this study, positron emission tomography using [18F]-2-fluoro-2- deoxy-d-glucose successfully guided surgeons to identify the most hypermetabolic and, therefore, the most suitable biopsy sites of huge soft tissue sarcoma.",

keywords = "FDG PET, MR, Metabolic biopsy, Sarcoma, Soft tissue tumor",

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AU - Park, Jong Hoon

AU - Park, Eun Kyung

AU - Kang, Chang Ho

AU - Kim, Chul Hwan

AU - Choe, Jae Gol

AU - Noh, Won

PY - 2009/12

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N2 - Soft tissue sarcomas are a highly heterogeneous group of malignancies that arise from mesenchymal tissues. Grading of soft tissue sarcomas is an important prerequisite for the choice of therapy and estimation of prognosis. However, incisional biopsy of huge soft tissue sarcoma lesions frequently fails to provide an accurate diagnosis when there is a benign component, cystic changes and/or necrosis. MRI is helpful in evaluating the extent of the sarcoma lesion, vascularization, invasiveness and integrity of surrounding tissue, but definitive differentiation of benignity and malignancy is not possible with it. In this study, positron emission tomography using [18F]-2-fluoro-2- deoxy-d-glucose successfully guided surgeons to identify the most hypermetabolic and, therefore, the most suitable biopsy sites of huge soft tissue sarcoma.

AB - Soft tissue sarcomas are a highly heterogeneous group of malignancies that arise from mesenchymal tissues. Grading of soft tissue sarcomas is an important prerequisite for the choice of therapy and estimation of prognosis. However, incisional biopsy of huge soft tissue sarcoma lesions frequently fails to provide an accurate diagnosis when there is a benign component, cystic changes and/or necrosis. MRI is helpful in evaluating the extent of the sarcoma lesion, vascularization, invasiveness and integrity of surrounding tissue, but definitive differentiation of benignity and malignancy is not possible with it. In this study, positron emission tomography using [18F]-2-fluoro-2- deoxy-d-glucose successfully guided surgeons to identify the most hypermetabolic and, therefore, the most suitable biopsy sites of huge soft tissue sarcoma.

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