Interatrial septal thickness as a marker of structural and functional remodeling of the left atrium in patients with atrial fibrillation

Hong Euy Lim, Jin Oh Na, Sung Il Im, Cheol Ung Choi, Seong Hwan Kim, Jin Won Kim, Eung Ju Kim, Seong Woo Han, Seung Woon Rha, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Chun Hwang

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6 Citations (Scopus)


Background/Aims: There have been reports that interatrial septal (IAS) thickness is increased in patients with atrial fibrillation (AF). This study was performed to investigate whether IAS thickness determined by transthoracic echocardiography (TTE) represents the amount of left atrium (LA) structural and functional remodeling. Methods: The study population consisted of 104 consecutive patients who underwent catheter ablation (CA) for AF (paroxysmal atrial fibrillation [PAF], 82; persistent atrial fibrillation [PeAF], 22). IAS thickness and left atrium volume (LAV) using TTE, and LA voltage (LAVOL) using 3-dimensional electroanatomical mapping system were assessed during sinus rhythm. Results: IAS thickness was significantly correlated with maximal LAV (LAVmax) (r = 0.288, p = 0.003), mean LAVOL (r = –0.537, p < 0.001), total left atrium emptying fraction (LAEFtotal;r = –0.213, p = 0.030), and active LAEF (LAEFactive; r = –0.249, p = 0.014). IAS thickness was greater in the high-risk group (≥ 2) compared to other groups according to CHA2DS2-VASc score (p = 0.019). During a follow-up of 19.6 months, 23 subjects (22.1%; PAF, 17; PeAF, 6) had recurrence of arrhythmia. Univariate analysis showed that LAVmax, minimal LAV, mean LAVOL, LVEFtotal, LVEFactive, and IAS thickness were associated with recurrence of arrhythmia. However, on multivariate analysis, only mean LAVOL and LAEFactive were independent risk factors for recurrence. Conclusions: Although IAS thickness showed significant correlations with parameters for LA structural and functional remodeling, this parameter alone could not independently predict recurrence of arrhythmia after CA for AF.

Original languageEnglish
Pages (from-to)808-820
Number of pages13
JournalKorean Journal of Internal Medicine
Issue number6
Publication statusPublished - 2015 Nov

Bibliographical note

Publisher Copyright:
© 2015 The Korean Association of Internal Medicine.


  • Atrial fibrillation
  • Atrial remodeling
  • Atrial septum
  • Heart atria

ASJC Scopus subject areas

  • Internal Medicine


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