Interconnection of multichannel polyimide electrodes using anisotropic conductive films (ACFs) for biomedical applications

Dong Hyun Baek, Ji Soo Park, Eun Joong Lee, Su Jung Shin, Jin Hee Moon, James Jungho Pak, Sang Hoon Lee

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


In this paper, we propose a method for interconnecting soft polyimide (PI) electrodes using anisotropic conductive films (ACFs). Reliable and automated bonding was achieved through development of a desktop thermocompressive bonding device that could simultaneously deliver appropriate temperatures and pressures to the interconnection area. The bonding conditions were optimized by changing the bonding temperature and bonding pressure. The electrical properties were characterized by measuring the contact resistance of the ACF bonding area, yielding a measure that was used to optimize the applied pressure and temperature. The optimal conditions consisted of applying a pressure of 4 kgf/cm2 and a temperature of 180 °C for 20 s. Although ACF base bonding is widely used in industry (e.g., liquid crystal display manufacturing), this study constitutes the first trial of a biomedical application. We performed a preliminary in vivo biocompatibility investigation of ACF bonded area. Using the optimized temperature and pressure conditions, we interconnected a 40-channel PI multielectrode device for measuring electroencephalography (EEG) signals from the skulls of mice. The electrical properties of electrode were characterized by measuring the impedance. Finally, EEG signals were measured from the mice skulls using the fabricated devices to investigate suitability for application to biomedical devices.

Original languageEnglish
Article number5674074
Pages (from-to)1466-1473
Number of pages8
JournalIEEE Transactions on Biomedical Engineering
Issue number5
Publication statusPublished - 2011 May

Bibliographical note

Funding Information:
Manuscript received April 3, 2010; revised September 24, 2010; accepted November 26, 2010. Date of publication December 23, 2010; date of current version April 20, 2011. This work was supported in part by the Strategic Technology Development Program of Ministry of Knowledge Economy under Grant 10031779 and in part by the Korea Healthcare technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea under Grant A092052-0911-0000200. Asterisk indicates corresponding author.


  • Biomedical engineering
  • biomedical electrodes
  • packaging
  • polyimide (PI) films

ASJC Scopus subject areas

  • Biomedical Engineering


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