Interleukin-18/-607 gene polymorphism in allergic rhinitis

Heung Man Lee, Sook Ah Park, Seung Won Chung, Jeong Soo Woo, Sung Won Chae, Sang Hag Lee, Hee Joon Kang, Soon Jae Hwang

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Objectives: Allergic rhinitis is a chronic inflammatory disease with a genetic background, and IL-18 (formerly IFN-γ-inducing factor) is a well-known pro-inflammatory cytokine. The aim of this study was to investigate whether the IL-18/-607 promoter polymorphisms were associated with allergic rhinitis in the Korean population. Study design: Prospective study. Methods: Deoxyribonucleic acid was obtained from the blood samples of 160 Korean children with allergic rhinitis and from 166 healthy controls. The IL-18/-607 polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Results: The frequency of the AC genotype of the IL-18/-607 gene polymorphism was significantly greater in allergic rhinitis patients than in controls (P < 0.05). Conclusions: The A allele in the IL-18/-607 gene promoter region may be involved in the development of allergic rhinitis in the Korean population.

Original languageEnglish
Pages (from-to)1085-1088
Number of pages4
JournalInternational Journal of Pediatric Otorhinolaryngology
Issue number6
Publication statusPublished - 2006 Jun

Bibliographical note

Funding Information:
This work was supported by the Brain Korea 21 Project of the Ministry of Education and Human Resources Development, Republic of Korea, in 2005.


  • Allergic rhinitis
  • IL-18 gene polymorphism

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Otorhinolaryngology


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