Interleukin-18/-607 gene polymorphism in allergic rhinitis

Heung Man Lee; Sook Ah Park; Seung Won Chung; Jeong Soo Woo; Sung Won Chae; Sang Hag Lee; Hee Joon Kang; Soon Jae Hwang

doi:10.1016/j.ijporl.2005.11.006

Interleukin-18/-607 gene polymorphism in allergic rhinitis

Heung Man Lee, Sook Ah Park, Seung Won Chung, Jeong Soo Woo, Sung Won Chae, Sang Hag Lee, Hee Joon Kang, Soon Jae Hwang

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Objectives: Allergic rhinitis is a chronic inflammatory disease with a genetic background, and IL-18 (formerly IFN-γ-inducing factor) is a well-known pro-inflammatory cytokine. The aim of this study was to investigate whether the IL-18/-607 promoter polymorphisms were associated with allergic rhinitis in the Korean population. Study design: Prospective study. Methods: Deoxyribonucleic acid was obtained from the blood samples of 160 Korean children with allergic rhinitis and from 166 healthy controls. The IL-18/-607 polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Results: The frequency of the AC genotype of the IL-18/-607 gene polymorphism was significantly greater in allergic rhinitis patients than in controls (P < 0.05). Conclusions: The A allele in the IL-18/-607 gene promoter region may be involved in the development of allergic rhinitis in the Korean population.

Original language	English
Pages (from-to)	1085-1088
Number of pages	4
Journal	International Journal of Pediatric Otorhinolaryngology
Volume	70
Issue number	6
DOIs	https://doi.org/10.1016/j.ijporl.2005.11.006
Publication status	Published - 2006 Jun

Bibliographical note

Funding Information:
This work was supported by the Brain Korea 21 Project of the Ministry of Education and Human Resources Development, Republic of Korea, in 2005.

Keywords

Allergic rhinitis
IL-18 gene polymorphism

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Otorhinolaryngology

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10.1016/j.ijporl.2005.11.006

Cite this

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title = "Interleukin-18/-607 gene polymorphism in allergic rhinitis",

abstract = "Objectives: Allergic rhinitis is a chronic inflammatory disease with a genetic background, and IL-18 (formerly IFN-γ-inducing factor) is a well-known pro-inflammatory cytokine. The aim of this study was to investigate whether the IL-18/-607 promoter polymorphisms were associated with allergic rhinitis in the Korean population. Study design: Prospective study. Methods: Deoxyribonucleic acid was obtained from the blood samples of 160 Korean children with allergic rhinitis and from 166 healthy controls. The IL-18/-607 polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Results: The frequency of the AC genotype of the IL-18/-607 gene polymorphism was significantly greater in allergic rhinitis patients than in controls (P < 0.05). Conclusions: The A allele in the IL-18/-607 gene promoter region may be involved in the development of allergic rhinitis in the Korean population.",

keywords = "Allergic rhinitis, IL-18 gene polymorphism",

author = "Lee, {Heung Man} and Park, {Sook Ah} and Chung, {Seung Won} and Woo, {Jeong Soo} and Chae, {Sung Won} and Lee, {Sang Hag} and Kang, {Hee Joon} and Hwang, {Soon Jae}",

note = "Funding Information: This work was supported by the Brain Korea 21 Project of the Ministry of Education and Human Resources Development, Republic of Korea, in 2005.",

year = "2006",

month = jun,

doi = "10.1016/j.ijporl.2005.11.006",

language = "English",

volume = "70",

pages = "1085--1088",

journal = "International Journal of Pediatric Otorhinolaryngology",

issn = "0165-5876",

publisher = "Elsevier Ireland Ltd",

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TY - JOUR

T1 - Interleukin-18/-607 gene polymorphism in allergic rhinitis

AU - Lee, Heung Man

AU - Park, Sook Ah

AU - Chung, Seung Won

AU - Woo, Jeong Soo

AU - Chae, Sung Won

AU - Lee, Sang Hag

AU - Kang, Hee Joon

AU - Hwang, Soon Jae

N1 - Funding Information: This work was supported by the Brain Korea 21 Project of the Ministry of Education and Human Resources Development, Republic of Korea, in 2005.

PY - 2006/6

Y1 - 2006/6

N2 - Objectives: Allergic rhinitis is a chronic inflammatory disease with a genetic background, and IL-18 (formerly IFN-γ-inducing factor) is a well-known pro-inflammatory cytokine. The aim of this study was to investigate whether the IL-18/-607 promoter polymorphisms were associated with allergic rhinitis in the Korean population. Study design: Prospective study. Methods: Deoxyribonucleic acid was obtained from the blood samples of 160 Korean children with allergic rhinitis and from 166 healthy controls. The IL-18/-607 polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Results: The frequency of the AC genotype of the IL-18/-607 gene polymorphism was significantly greater in allergic rhinitis patients than in controls (P < 0.05). Conclusions: The A allele in the IL-18/-607 gene promoter region may be involved in the development of allergic rhinitis in the Korean population.

AB - Objectives: Allergic rhinitis is a chronic inflammatory disease with a genetic background, and IL-18 (formerly IFN-γ-inducing factor) is a well-known pro-inflammatory cytokine. The aim of this study was to investigate whether the IL-18/-607 promoter polymorphisms were associated with allergic rhinitis in the Korean population. Study design: Prospective study. Methods: Deoxyribonucleic acid was obtained from the blood samples of 160 Korean children with allergic rhinitis and from 166 healthy controls. The IL-18/-607 polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Results: The frequency of the AC genotype of the IL-18/-607 gene polymorphism was significantly greater in allergic rhinitis patients than in controls (P < 0.05). Conclusions: The A allele in the IL-18/-607 gene promoter region may be involved in the development of allergic rhinitis in the Korean population.

KW - Allergic rhinitis

KW - IL-18 gene polymorphism

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SN - 0165-5876

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SP - 1085

EP - 1088

JO - International Journal of Pediatric Otorhinolaryngology

JF - International Journal of Pediatric Otorhinolaryngology

IS - 6

ER -

Interleukin-18/-607 gene polymorphism in allergic rhinitis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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