Objectives: Allergic rhinitis is a chronic inflammatory disease with a genetic background, and IL-18 (formerly IFN-γ-inducing factor) is a well-known pro-inflammatory cytokine. The aim of this study was to investigate whether the IL-18/-607 promoter polymorphisms were associated with allergic rhinitis in the Korean population. Study design: Prospective study. Methods: Deoxyribonucleic acid was obtained from the blood samples of 160 Korean children with allergic rhinitis and from 166 healthy controls. The IL-18/-607 polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Results: The frequency of the AC genotype of the IL-18/-607 gene polymorphism was significantly greater in allergic rhinitis patients than in controls (P < 0.05). Conclusions: The A allele in the IL-18/-607 gene promoter region may be involved in the development of allergic rhinitis in the Korean population.
|Number of pages||4|
|Journal||International Journal of Pediatric Otorhinolaryngology|
|Publication status||Published - 2006 Jun|
Bibliographical noteFunding Information:
This work was supported by the Brain Korea 21 Project of the Ministry of Education and Human Resources Development, Republic of Korea, in 2005.
- Allergic rhinitis
- IL-18 gene polymorphism
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health