Interleukin-18/-607 gene polymorphism in allergic rhinitis

Heung Man Lee; Sook Ah Park; Seung Won Chung; Jeong-Soo Woo; Sung Won Chae; Sang Hag Lee; Hee Joon Kang; Soon Jae Hwang

doi:10.1016/j.ijporl.2005.11.006

Interleukin-18/-607 gene polymorphism in allergic rhinitis

Heung Man Lee^*
, Sook Ah Park
, Seung Won Chung
, Jeong-Soo Woo
, Sung Won Chae
, Sang Hag Lee
, Hee Joon Kang
, Soon Jae Hwang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Objectives: Allergic rhinitis is a chronic inflammatory disease with a genetic background, and IL-18 (formerly IFN-γ-inducing factor) is a well-known pro-inflammatory cytokine. The aim of this study was to investigate whether the IL-18/-607 promoter polymorphisms were associated with allergic rhinitis in the Korean population. Study design: Prospective study. Methods: Deoxyribonucleic acid was obtained from the blood samples of 160 Korean children with allergic rhinitis and from 166 healthy controls. The IL-18/-607 polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Results: The frequency of the AC genotype of the IL-18/-607 gene polymorphism was significantly greater in allergic rhinitis patients than in controls (P < 0.05). Conclusions: The A allele in the IL-18/-607 gene promoter region may be involved in the development of allergic rhinitis in the Korean population.

Original language	English
Pages (from-to)	1085-1088
Number of pages	4
Journal	International Journal of Pediatric Otorhinolaryngology
Volume	70
Issue number	6
DOIs	https://doi.org/10.1016/j.ijporl.2005.11.006
Publication status	Published - 2006 Jun

Bibliographical note

Funding Information:
This work was supported by the Brain Korea 21 Project of the Ministry of Education and Human Resources Development, Republic of Korea, in 2005.

Keywords

Allergic rhinitis
IL-18 gene polymorphism

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Otorhinolaryngology

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10.1016/j.ijporl.2005.11.006

Cite this

@article{6fe45251fe0c47228a0ce6a0860938d3,

title = "Interleukin-18/-607 gene polymorphism in allergic rhinitis",

abstract = "Objectives: Allergic rhinitis is a chronic inflammatory disease with a genetic background, and IL-18 (formerly IFN-γ-inducing factor) is a well-known pro-inflammatory cytokine. The aim of this study was to investigate whether the IL-18/-607 promoter polymorphisms were associated with allergic rhinitis in the Korean population. Study design: Prospective study. Methods: Deoxyribonucleic acid was obtained from the blood samples of 160 Korean children with allergic rhinitis and from 166 healthy controls. The IL-18/-607 polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Results: The frequency of the AC genotype of the IL-18/-607 gene polymorphism was significantly greater in allergic rhinitis patients than in controls (P < 0.05). Conclusions: The A allele in the IL-18/-607 gene promoter region may be involved in the development of allergic rhinitis in the Korean population.",

keywords = "Allergic rhinitis, IL-18 gene polymorphism",

author = "Lee, \{Heung Man\} and Park, \{Sook Ah\} and Chung, \{Seung Won\} and Jeong-Soo Woo and Chae, \{Sung Won\} and Lee, \{Sang Hag\} and Kang, \{Hee Joon\} and Hwang, \{Soon Jae\}",

note = "Funding Information: This work was supported by the Brain Korea 21 Project of the Ministry of Education and Human Resources Development, Republic of Korea, in 2005.",

year = "2006",

month = jun,

doi = "10.1016/j.ijporl.2005.11.006",

language = "English",

volume = "70",

pages = "1085--1088",

journal = "International Journal of Pediatric Otorhinolaryngology",

issn = "0165-5876",

publisher = "Elsevier Ireland Ltd",

number = "6",

}

TY - JOUR

T1 - Interleukin-18/-607 gene polymorphism in allergic rhinitis

AU - Lee, Heung Man

AU - Park, Sook Ah

AU - Chung, Seung Won

AU - Woo, Jeong-Soo

AU - Chae, Sung Won

AU - Lee, Sang Hag

AU - Kang, Hee Joon

AU - Hwang, Soon Jae

N1 - Funding Information: This work was supported by the Brain Korea 21 Project of the Ministry of Education and Human Resources Development, Republic of Korea, in 2005.

PY - 2006/6

Y1 - 2006/6

N2 - Objectives: Allergic rhinitis is a chronic inflammatory disease with a genetic background, and IL-18 (formerly IFN-γ-inducing factor) is a well-known pro-inflammatory cytokine. The aim of this study was to investigate whether the IL-18/-607 promoter polymorphisms were associated with allergic rhinitis in the Korean population. Study design: Prospective study. Methods: Deoxyribonucleic acid was obtained from the blood samples of 160 Korean children with allergic rhinitis and from 166 healthy controls. The IL-18/-607 polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Results: The frequency of the AC genotype of the IL-18/-607 gene polymorphism was significantly greater in allergic rhinitis patients than in controls (P < 0.05). Conclusions: The A allele in the IL-18/-607 gene promoter region may be involved in the development of allergic rhinitis in the Korean population.

AB - Objectives: Allergic rhinitis is a chronic inflammatory disease with a genetic background, and IL-18 (formerly IFN-γ-inducing factor) is a well-known pro-inflammatory cytokine. The aim of this study was to investigate whether the IL-18/-607 promoter polymorphisms were associated with allergic rhinitis in the Korean population. Study design: Prospective study. Methods: Deoxyribonucleic acid was obtained from the blood samples of 160 Korean children with allergic rhinitis and from 166 healthy controls. The IL-18/-607 polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Results: The frequency of the AC genotype of the IL-18/-607 gene polymorphism was significantly greater in allergic rhinitis patients than in controls (P < 0.05). Conclusions: The A allele in the IL-18/-607 gene promoter region may be involved in the development of allergic rhinitis in the Korean population.

KW - Allergic rhinitis

KW - IL-18 gene polymorphism

UR - https://www.scopus.com/pages/publications/33646091092

U2 - 10.1016/j.ijporl.2005.11.006

DO - 10.1016/j.ijporl.2005.11.006

M3 - Article

C2 - 16406079

AN - SCOPUS:33646091092

SN - 0165-5876

VL - 70

SP - 1085

EP - 1088

JO - International Journal of Pediatric Otorhinolaryngology

JF - International Journal of Pediatric Otorhinolaryngology

IS - 6

ER -

Interleukin-18/-607 gene polymorphism in allergic rhinitis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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