Interleukin-18 induces transferrin expression in breast cancer cell line MCF-7

Sunyoung Park; Sun Young Yoon; Kyung Eun Kim; Ha Reum Lee; Dae Young Hur; Hyunkeun Song; Daejin Kim; Sa Ik Bang; Dae Ho Cho

doi:10.1016/j.canlet.2009.05.025

Interleukin-18 induces transferrin expression in breast cancer cell line MCF-7

Sunyoung Park, Sun Young Yoon, Kyung Eun Kim, Ha Reum Lee, Dae Young Hur, Hyunkeun Song, Daejin Kim, Sa Ik Bang, Dae Ho Cho

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Interleukin-18 (IL-18) has recently been shown to have a pro-cancer effect in various cancers. Increased serum levels of both IL-18 and transferrin in cancer patients are correlated with its malignancy. However, the relationship between transferrin and IL-18 is not well understood. Here, we show that exogenous transferrin enhanced breast cancer cell proliferation and the proliferation rate was reduced when endogenous transferrin expression was inhibited by transferrin siRNA. The expression of endogenous transferrin was found to be regulated by IL-18. Furthermore, we found that the MAPK pathway is involved in IL-18-induced transferrin production. In conclusion, IL-18 is suggested as an inducer of endogenous transferrin expression in breast cancer cells.

Original language	English
Pages (from-to)	189-195
Number of pages	7
Journal	Cancer letters
Volume	286
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2009.05.025
Publication status	Published - 2009 Dec 28
Externally published	Yes

Keywords

Breast cancer
Interleukin-18 (IL-18)
Proliferation
Transferrin

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2009.05.025

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@article{e816656efd4b466fa4ef57345e3897bf,

title = "Interleukin-18 induces transferrin expression in breast cancer cell line MCF-7",

abstract = "Interleukin-18 (IL-18) has recently been shown to have a pro-cancer effect in various cancers. Increased serum levels of both IL-18 and transferrin in cancer patients are correlated with its malignancy. However, the relationship between transferrin and IL-18 is not well understood. Here, we show that exogenous transferrin enhanced breast cancer cell proliferation and the proliferation rate was reduced when endogenous transferrin expression was inhibited by transferrin siRNA. The expression of endogenous transferrin was found to be regulated by IL-18. Furthermore, we found that the MAPK pathway is involved in IL-18-induced transferrin production. In conclusion, IL-18 is suggested as an inducer of endogenous transferrin expression in breast cancer cells.",

keywords = "Breast cancer, Interleukin-18 (IL-18), Proliferation, Transferrin",

author = "Sunyoung Park and Yoon, {Sun Young} and Kim, {Kyung Eun} and Lee, {Ha Reum} and Hur, {Dae Young} and Hyunkeun Song and Daejin Kim and Bang, {Sa Ik} and Cho, {Dae Ho}",

note = "Funding Information: This work was supported by the Korea Science & Engineering Foundation (KOSEF) through the Research Center for Women{\textquoteright}s Disease (RCWD) at Sookmyung Women{\textquoteright}s University, the Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2006-005-J02202) and Seoul Research and Business Development Program (10582).",

year = "2009",

month = dec,

day = "28",

doi = "10.1016/j.canlet.2009.05.025",

language = "English",

volume = "286",

pages = "189--195",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Interleukin-18 induces transferrin expression in breast cancer cell line MCF-7

AU - Park, Sunyoung

AU - Yoon, Sun Young

AU - Kim, Kyung Eun

AU - Lee, Ha Reum

AU - Hur, Dae Young

AU - Song, Hyunkeun

AU - Kim, Daejin

AU - Bang, Sa Ik

AU - Cho, Dae Ho

N1 - Funding Information: This work was supported by the Korea Science & Engineering Foundation (KOSEF) through the Research Center for Women’s Disease (RCWD) at Sookmyung Women’s University, the Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2006-005-J02202) and Seoul Research and Business Development Program (10582).

PY - 2009/12/28

Y1 - 2009/12/28

N2 - Interleukin-18 (IL-18) has recently been shown to have a pro-cancer effect in various cancers. Increased serum levels of both IL-18 and transferrin in cancer patients are correlated with its malignancy. However, the relationship between transferrin and IL-18 is not well understood. Here, we show that exogenous transferrin enhanced breast cancer cell proliferation and the proliferation rate was reduced when endogenous transferrin expression was inhibited by transferrin siRNA. The expression of endogenous transferrin was found to be regulated by IL-18. Furthermore, we found that the MAPK pathway is involved in IL-18-induced transferrin production. In conclusion, IL-18 is suggested as an inducer of endogenous transferrin expression in breast cancer cells.

AB - Interleukin-18 (IL-18) has recently been shown to have a pro-cancer effect in various cancers. Increased serum levels of both IL-18 and transferrin in cancer patients are correlated with its malignancy. However, the relationship between transferrin and IL-18 is not well understood. Here, we show that exogenous transferrin enhanced breast cancer cell proliferation and the proliferation rate was reduced when endogenous transferrin expression was inhibited by transferrin siRNA. The expression of endogenous transferrin was found to be regulated by IL-18. Furthermore, we found that the MAPK pathway is involved in IL-18-induced transferrin production. In conclusion, IL-18 is suggested as an inducer of endogenous transferrin expression in breast cancer cells.

KW - Breast cancer

KW - Interleukin-18 (IL-18)

KW - Proliferation

KW - Transferrin

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U2 - 10.1016/j.canlet.2009.05.025

DO - 10.1016/j.canlet.2009.05.025

M3 - Article

C2 - 19535202

AN - SCOPUS:71549130413

SN - 0304-3835

VL - 286

SP - 189

EP - 195

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Interleukin-18 induces transferrin expression in breast cancer cell line MCF-7

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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