Interleukin-4 induces senescence in human renal carcinoma cell lines through STAT6 and p38 MAPK

Hag Dong Kim; Su Jin Yu; Hee Suk Kim; Yong Jin Kim; Jeong Min Choe; Yun Gyu Park; Joon Kim; Jeongwon Sohn

doi:10.1074/jbc.M113.499053

Interleukin-4 induces senescence in human renal carcinoma cell lines through STAT6 and p38 MAPK

Hag Dong Kim, Su Jin Yu, Hee Suk Kim, Yong Jin Kim, Jeong Min Choe, Yun Gyu Park, Joon Kim, Jeongwon Sohn

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Background:IL-4 can directly inhibit growth of several tumor cell types, but the molecular mechanism is not known. Results:IL-4 induces senescence by increasing p21 WAF1/CIP1 expression through STAT6 and p38 MAPK. Conclusion:STAT6 and p38 MAPK play important roles in senescence induction by IL-4. Significance:This is the first report of cellular senescence induction by IL-4 and the responsible mechanism.

Original language	English
Pages (from-to)	28743-28754
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	40
DOIs	https://doi.org/10.1074/jbc.M113.499053
Publication status	Published - 2013 Oct 4

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Interleukin-4 induces senescence in human renal carcinoma cell lines through STAT6 and p38 MAPK",

abstract = "Background:IL-4 can directly inhibit growth of several tumor cell types, but the molecular mechanism is not known. Results:IL-4 induces senescence by increasing p21 WAF1/CIP1 expression through STAT6 and p38 MAPK. Conclusion:STAT6 and p38 MAPK play important roles in senescence induction by IL-4. Significance:This is the first report of cellular senescence induction by IL-4 and the responsible mechanism.",

author = "Kim, {Hag Dong} and Yu, {Su Jin} and Kim, {Hee Suk} and Kim, {Yong Jin} and Choe, {Jeong Min} and Park, {Yun Gyu} and Joon Kim and Jeongwon Sohn",

year = "2013",

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doi = "10.1074/jbc.M113.499053",

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T1 - Interleukin-4 induces senescence in human renal carcinoma cell lines through STAT6 and p38 MAPK

AU - Kim, Hag Dong

AU - Yu, Su Jin

AU - Kim, Hee Suk

AU - Kim, Yong Jin

AU - Choe, Jeong Min

AU - Park, Yun Gyu

AU - Kim, Joon

AU - Sohn, Jeongwon

PY - 2013/10/4

Y1 - 2013/10/4

N2 - Background:IL-4 can directly inhibit growth of several tumor cell types, but the molecular mechanism is not known. Results:IL-4 induces senescence by increasing p21 WAF1/CIP1 expression through STAT6 and p38 MAPK. Conclusion:STAT6 and p38 MAPK play important roles in senescence induction by IL-4. Significance:This is the first report of cellular senescence induction by IL-4 and the responsible mechanism.

AB - Background:IL-4 can directly inhibit growth of several tumor cell types, but the molecular mechanism is not known. Results:IL-4 induces senescence by increasing p21 WAF1/CIP1 expression through STAT6 and p38 MAPK. Conclusion:STAT6 and p38 MAPK play important roles in senescence induction by IL-4. Significance:This is the first report of cellular senescence induction by IL-4 and the responsible mechanism.

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U2 - 10.1074/jbc.M113.499053

DO - 10.1074/jbc.M113.499053

M3 - Article

C2 - 23935100

AN - SCOPUS:84885158864

SN - 0021-9258

VL - 288

SP - 28743

EP - 28754

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 40

ER -

Interleukin-4 induces senescence in human renal carcinoma cell lines through STAT6 and p38 MAPK

Abstract

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