Interleukin-4 induces senescence in human renal carcinoma cell lines through STAT6 and p38 MAPK

Hag Dong Kim; Su Jin Yu; Hee Suk Kim; Yong Jin Kim; Jeong Min Choe; Yun Gyu Park; Joon Kim; Jeongwon Sohn

doi:10.1074/jbc.M113.499053

Interleukin-4 induces senescence in human renal carcinoma cell lines through STAT6 and p38 MAPK

Hag Dong Kim
, Su Jin Yu
, Hee Suk Kim
, Yong Jin Kim
, Jeong Min Choe
, Yun Gyu Park
, Joon Kim
, Jeongwon Sohn^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Background:IL-4 can directly inhibit growth of several tumor cell types, but the molecular mechanism is not known. Results:IL-4 induces senescence by increasing p21 WAF1/CIP1 expression through STAT6 and p38 MAPK. Conclusion:STAT6 and p38 MAPK play important roles in senescence induction by IL-4. Significance:This is the first report of cellular senescence induction by IL-4 and the responsible mechanism.

Original language	English
Pages (from-to)	28743-28754
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	40
DOIs	https://doi.org/10.1074/jbc.M113.499053
Publication status	Published - 2013 Oct 4

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Interleukin-4 induces senescence in human renal carcinoma cell lines through STAT6 and p38 MAPK",

abstract = "Background:IL-4 can directly inhibit growth of several tumor cell types, but the molecular mechanism is not known. Results:IL-4 induces senescence by increasing p21 WAF1/CIP1 expression through STAT6 and p38 MAPK. Conclusion:STAT6 and p38 MAPK play important roles in senescence induction by IL-4. Significance:This is the first report of cellular senescence induction by IL-4 and the responsible mechanism.",

author = "Kim, \{Hag Dong\} and Yu, \{Su Jin\} and Kim, \{Hee Suk\} and Kim, \{Yong Jin\} and Choe, \{Jeong Min\} and Park, \{Yun Gyu\} and Joon Kim and Jeongwon Sohn",

year = "2013",

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doi = "10.1074/jbc.M113.499053",

language = "English",

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T1 - Interleukin-4 induces senescence in human renal carcinoma cell lines through STAT6 and p38 MAPK

AU - Kim, Hag Dong

AU - Yu, Su Jin

AU - Kim, Hee Suk

AU - Kim, Yong Jin

AU - Choe, Jeong Min

AU - Park, Yun Gyu

AU - Kim, Joon

AU - Sohn, Jeongwon

PY - 2013/10/4

Y1 - 2013/10/4

N2 - Background:IL-4 can directly inhibit growth of several tumor cell types, but the molecular mechanism is not known. Results:IL-4 induces senescence by increasing p21 WAF1/CIP1 expression through STAT6 and p38 MAPK. Conclusion:STAT6 and p38 MAPK play important roles in senescence induction by IL-4. Significance:This is the first report of cellular senescence induction by IL-4 and the responsible mechanism.

AB - Background:IL-4 can directly inhibit growth of several tumor cell types, but the molecular mechanism is not known. Results:IL-4 induces senescence by increasing p21 WAF1/CIP1 expression through STAT6 and p38 MAPK. Conclusion:STAT6 and p38 MAPK play important roles in senescence induction by IL-4. Significance:This is the first report of cellular senescence induction by IL-4 and the responsible mechanism.

UR - https://www.scopus.com/pages/publications/84885158864

U2 - 10.1074/jbc.M113.499053

DO - 10.1074/jbc.M113.499053

M3 - Article

C2 - 23935100

AN - SCOPUS:84885158864

SN - 0021-9258

VL - 288

SP - 28743

EP - 28754

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 40

ER -

Interleukin-4 induces senescence in human renal carcinoma cell lines through STAT6 and p38 MAPK

Abstract

ASJC Scopus subject areas

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