Internal chelation-guided regio- and stereoselective Pauson-Khand-type reaction by chiral Rhodium(I) catalysis

Dong Eun Kim, Sang Hee Park, Yun Hee Choi, Sueg Geun Lee, Dohyun Moon, Jungju Seo, Nakcheol Jeong

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    Touch, Pauson, engage: To explain the unique superior reactivity and stereoselectivity of O-tethered enynes in asymmetric Pauson-Khand type reaction (APKR) than their congeners, the internal-chelation to metal of oxygen atom of the substrate in the transition state was proposed. This proposition was well supported by APKR with several different substrates.

    Original languageEnglish
    Pages (from-to)2009-2014
    Number of pages6
    JournalChemistry - An Asian Journal
    Volume6
    Issue number8
    DOIs
    Publication statusPublished - 2011 Aug 1

    Keywords

    • Pauson-Khand reaction
    • chelation effects
    • enantioselectivity
    • kinetic resolution
    • rhodium

    ASJC Scopus subject areas

    • General Chemistry
    • Biochemistry
    • Organic Chemistry

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