Internet-based control recruitment for a case-control study of major risk factors for stroke in Korea: Lessons from the experience

Jong Moo Park, Yong Jin Cho, Kyung Bok Lee, Tai Hwan Park, Soo Joo Lee, Moon Ku Han, Youngchai Ko, Jun Lee, Jae Kwan Cha, Byung Chul Lee, Kyung Ho Yu, Mi Sun Oh, Ji Sung Lee, Juneyoung Lee, Hee Joon Bae

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Background: This study aimed to estimate the population-attributable risks (PARs) of 9 major risk factors for stroke in Korea through a case-control study and to test the feasibility and validity of internet-based control recruitment. Methods: From April 2008 to September 2009 controls were enrolled via internet after providing consent for participation through a web-based survey. The cases included patients who were admitted to the participating centers due to acute stroke or transient ischemic attack within 7 days of onset during the study period. Each control was age- and sex-matched with 2 cases. Adjusted odd ratios, age-standardized prevalence, and PARs were estimated for the 9 major risk factors using the prevalence of risk factors in the control group and the age and sex characteristics from Korea's national census data. Results: In total, 1041 controls were matched to 2082 stroke cases. Because of a shortage of elderly controls in the internet-based recruitment, 248 controls were recruited off-line. The PARs were 23.44%, 10.95%, 51.32%, and 6.35% for hypertension, diabetes, smoking, and stroke history, respectively. Hypercholesterolemia, atrial fibrillation, obesity, coronary heart disease, and a family history of stroke were not associated with stroke. Comparison with education and religion of the control group with that mentioned in the national census data showed a notable difference. Conclusions: The study results imply that internet-based control recruitment for a case- control study requires careful selection of risk factors with high self-awareness and effective strategies to facilitate the recruitment of elderly participants.

Original languageEnglish
Pages (from-to)2559-2565
Number of pages7
JournalJournal of Stroke and Cerebrovascular Diseases
Issue number10
Publication statusPublished - 2014
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Healthcare technology R&D Project , Ministry of Health and Welfare , Republic of Korea ( HI10C2020 ).

Publisher Copyright:
© 2014 by National Stroke Association.


  • Based study
  • Case
  • Control study
  • Internet
  • Risk factors
  • Stroke

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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