Interrogating Fiber Formation Kinetics with Automated 2D-IR Spectroscopy

David B. Strasfeld, Yun L. Ling, Sang Hee Shim, Martin T. Zanni

Research output: Chapter in Book/Report/Conference proceedingChapter


A new method for collecting 2D-IR spectra that utilizes both a pump-probe beam geometry and a mid-IR pulse shaper is used to gain a fuller understanding of fiber formation in the human islet amyloid polypeptide (hIAPP). We extract structural kinetics in order to better understand aggregation in hIAPP, the protein component of the amyloid fibers found to inhibit insulin production in type II diabetes patients.

Original languageEnglish
Title of host publicationSpringer Series in Chemical Physics
PublisherSpringer Science and Business Media Deutschland GmbH
Number of pages3
Publication statusPublished - 2009
Externally publishedYes

Publication series

NameSpringer Series in Chemical Physics
ISSN (Print)0172-6218

Bibliographical note

Funding Information:
We acknowledge the contributions of Dan Raleigh and Peter Marek from SUNY – Stony Brook for synthesizing the isotope labeled hIAPP. Funding comes from the NSF (CHE-0350518), the Packard Foundation, and the NIH (R21AI064797, R01DK079895).

Publisher Copyright:
© 2009, Springer-Verlag Berlin Heidelberg.


  • Amyloid Fiber
  • Amyloid Formation
  • Cross Peak
  • Fiber Formation
  • Random Coil

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry


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