Interrogating Fiber Formation Kinetics with Automated 2D-IR Spectroscopy

David B. Strasfeld; Yun L. Ling; Sang Hee Shim; Martin T. Zanni

doi:10.1007/978-3-540-95946-5_177

Interrogating Fiber Formation Kinetics with Automated 2D-IR Spectroscopy

David B. Strasfeld, Yun L. Ling, Sang Hee Shim, Martin T. Zanni

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

A new method for collecting 2D-IR spectra that utilizes both a pump-probe beam geometry and a mid-IR pulse shaper is used to gain a fuller understanding of fiber formation in the human islet amyloid polypeptide (hIAPP). We extract structural kinetics in order to better understand aggregation in hIAPP, the protein component of the amyloid fibers found to inhibit insulin production in type II diabetes patients.

Original language	English
Title of host publication	Springer Series in Chemical Physics
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	547-549
Number of pages	3
DOIs	https://doi.org/10.1007/978-3-540-95946-5_177
Publication status	Published - 2009
Externally published	Yes

Publication series

Name	Springer Series in Chemical Physics
Volume	92
ISSN (Print)	0172-6218

Bibliographical note

Funding Information:
We acknowledge the contributions of Dan Raleigh and Peter Marek from SUNY – Stony Brook for synthesizing the isotope labeled hIAPP. Funding comes from the NSF (CHE-0350518), the Packard Foundation, and the NIH (R21AI064797, R01DK079895).

Publisher Copyright:
© 2009, Springer-Verlag Berlin Heidelberg.

Keywords

Amyloid Fiber
Amyloid Formation
Cross Peak
Fiber Formation
Random Coil

ASJC Scopus subject areas

Physical and Theoretical Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-540-95946-5_177

Cite this

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title = "Interrogating Fiber Formation Kinetics with Automated 2D-IR Spectroscopy",

abstract = "A new method for collecting 2D-IR spectra that utilizes both a pump-probe beam geometry and a mid-IR pulse shaper is used to gain a fuller understanding of fiber formation in the human islet amyloid polypeptide (hIAPP). We extract structural kinetics in order to better understand aggregation in hIAPP, the protein component of the amyloid fibers found to inhibit insulin production in type II diabetes patients.",

keywords = "Amyloid Fiber, Amyloid Formation, Cross Peak, Fiber Formation, Random Coil",

author = "Strasfeld, {David B.} and Ling, {Yun L.} and Shim, {Sang Hee} and Zanni, {Martin T.}",

note = "Funding Information: We acknowledge the contributions of Dan Raleigh and Peter Marek from SUNY – Stony Brook for synthesizing the isotope labeled hIAPP. Funding comes from the NSF (CHE-0350518), the Packard Foundation, and the NIH (R21AI064797, R01DK079895). Publisher Copyright: {\textcopyright} 2009, Springer-Verlag Berlin Heidelberg.",

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doi = "10.1007/978-3-540-95946-5_177",

language = "English",

series = "Springer Series in Chemical Physics",

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AU - Strasfeld, David B.

AU - Ling, Yun L.

AU - Shim, Sang Hee

AU - Zanni, Martin T.

N1 - Funding Information: We acknowledge the contributions of Dan Raleigh and Peter Marek from SUNY – Stony Brook for synthesizing the isotope labeled hIAPP. Funding comes from the NSF (CHE-0350518), the Packard Foundation, and the NIH (R21AI064797, R01DK079895). Publisher Copyright: © 2009, Springer-Verlag Berlin Heidelberg.

PY - 2009

Y1 - 2009

N2 - A new method for collecting 2D-IR spectra that utilizes both a pump-probe beam geometry and a mid-IR pulse shaper is used to gain a fuller understanding of fiber formation in the human islet amyloid polypeptide (hIAPP). We extract structural kinetics in order to better understand aggregation in hIAPP, the protein component of the amyloid fibers found to inhibit insulin production in type II diabetes patients.

AB - A new method for collecting 2D-IR spectra that utilizes both a pump-probe beam geometry and a mid-IR pulse shaper is used to gain a fuller understanding of fiber formation in the human islet amyloid polypeptide (hIAPP). We extract structural kinetics in order to better understand aggregation in hIAPP, the protein component of the amyloid fibers found to inhibit insulin production in type II diabetes patients.

KW - Amyloid Fiber

KW - Amyloid Formation

KW - Cross Peak

KW - Fiber Formation

KW - Random Coil

UR - http://www.scopus.com/inward/record.url?scp=85122361472&partnerID=8YFLogxK

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DO - 10.1007/978-3-540-95946-5_177

M3 - Chapter

AN - SCOPUS:85122361472

T3 - Springer Series in Chemical Physics

SP - 547

EP - 549

BT - Springer Series in Chemical Physics

PB - Springer Science and Business Media Deutschland GmbH

ER -

Interrogating Fiber Formation Kinetics with Automated 2D-IR Spectroscopy

Abstract

Publication series

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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