Intra-mitochondrial self-assembly to overcome the intracellular enzymatic degradation ofl-peptides

M. T. Jeena, Seokyoung Lee, Ayan Kumar Barui, Seongeon Jin, Yuri Cho, Suk Won Hwang, Sehoon Kim, Ja Hyoung Ryu

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    The design of peptide-based therapeutics is generally based on the replacement ofl-amino acids withd-isomers to obtain improved therapeutic efficiency. However,d-isomers are expensive and frequently induce undesirable immune responses. In the present work, we demonstrate that an intra-mitochondrially self-assembling amphiphilic peptide exhibits analogous activity in bothd- andl-isomeric forms. This outcome is in contrast to the general observation considering higher therapeutic efficiencies ofd-isomers compared withl-analogues. This suggests thatl-peptides overcome proteolytic degradation during intra-mitochondrial self-assembly bothin vitroandin vivo.

    Original languageEnglish
    Pages (from-to)6265-6268
    Number of pages4
    JournalChemical Communications
    Volume56
    Issue number46
    DOIs
    Publication statusPublished - 2020 Jun 11

    Bibliographical note

    Funding Information:
    This work was supported by the National Research Foundation of Korea (2017R1A2B4003617, 2016R1A5A1009405, 2017K1A3A1A 19071083, 2018R1E1A2A02058946, 2019R1I1A1A01062414, and 2017M3A9D8029942) and the Korea Research Institute of Standards and Science (KRISS-2018-GP2018-0018) for KIST intramural program.

    Publisher Copyright:
    © The Royal Society of Chemistry 2020.

    ASJC Scopus subject areas

    • Catalysis
    • Electronic, Optical and Magnetic Materials
    • Ceramics and Composites
    • General Chemistry
    • Surfaces, Coatings and Films
    • Metals and Alloys
    • Materials Chemistry

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