Intratumoral phenotypic heterogeneity as an encourager of cancer invasion

Yoojin Shin, Sewoon Han, Euiheon Chung, Seok Chung

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


We present a novel in vitro breast tumor model to mimic intratumoral phenotypic heterogeneity based on a microfluidic system incorporating ECM scaffolds capable of providing a physiologically relevant tumor microenvironment. To study the regulation of invasive potentials by intratumoral subpopulation conditions, we developed heterogeneous cancer cell subpopulations by co-culturing two breast cancer cell types with distinct phenotypes, specifically, highly invasive and epithelial-like cancer cells. Our results indicate that intratumoral phenotypic heterogeneity acts as an encourager of cancer cell invasion through a 3D matrix depending on the neighboring ECM, with highly invasive cancer cells acting as the 'leader' and epithelial-like cancer cells as the 'follower', therefore enhancing the metastatic potential.

Original languageEnglish
Pages (from-to)654-661
Number of pages8
JournalIntegrative biology : quantitative biosciences from nano to macro
Issue number7
Publication statusPublished - 2014 Jul 24

ASJC Scopus subject areas

  • General Medicine


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