Intratympanic steroid injection for sudden sensorineural hearing loss: Impact of injection interval on therapeutic efficacy

Min Young Kwak; Chan Ju Yang; Hyun Joon Shim; Chan Il Song; Jong Yang Kim; Il Woo Lee; Sung Wook Jung; Hyun Woo Lim; Joong Keun Kwon; Jun Ho Lee; June Choi; Yun Suk An; Kyu Yup Lee; Jong Woo Chung

doi:10.1016/j.anl.2020.06.009

Intratympanic steroid injection for sudden sensorineural hearing loss: Impact of injection interval on therapeutic efficacy

Min Young Kwak, Chan Ju Yang, Hyun Joon Shim, Chan Il Song, Jong Yang Kim, Il Woo Lee, Sung Wook Jung, Hyun Woo Lim, Joong Keun Kwon, Jun Ho Lee, June Choi, Yun Suk An, Kyu Yup Lee, Jong Woo Chung

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Objective: To compare the effect of injection time intervals of intratympanic (IT) dexamethasone (DEX) in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Methods: Seventy-five adults with ISSNHL were grouped into four groups according to the IT DEX interval. In addition to concurrent oral steroid medication for two weeks, patients received IT DEX injections every 1, 2, 3, and four days, respectively. (Group 1, Group 2, Group 3, and Group 4). We evaluated the treatment outcomes according to modified criteria from “Clinical Practice Guideline: Sudden Hearing Loss” of the American Academy of Otolaryngology-Head and Neck Surgery (AAO–HNS) to justify treatment success. Results: There were no significant differences in demographic and baseline audiometric data. The mean of pure tone audiometry (PTA) and speech discrimination score (SDSs) were significantly improved after oral steroid and IT DEX treatment in all four groups. Group 1 showed significantly higher improvement than Group 4 in PTA after treatment. There was a significantly higher complete recovery (CR) rate in Group 1 than Group 4. Conclusion: We found a statistically significant difference in the complete hearing recovery rate and audiometric results (PTA) between the group with a daily interval of injections and the group with a four-day time interval. Therefore, daily time intervals in intratympanic steroid injection may be considered as an option for better improvement of hearing in patients with ISSNHL.

Original language	English
Pages (from-to)	982-989
Number of pages	8
Journal	Auris Nasus Larynx
Volume	47
Issue number	6
DOIs	https://doi.org/10.1016/j.anl.2020.06.009
Publication status	Published - 2020 Dec
Externally published	Yes

Bibliographical note

Funding Information:
This study was supported by a grant ( 2013–0455 ) from the Asan Institute for Life Sciences , Asan Medical Center, Seoul, Korea

Publisher Copyright:
© 2020

Keywords

Audiometry
Dexamethasone
Intratympanic
Sudden hearing loss

ASJC Scopus subject areas

Surgery
Otorhinolaryngology

Access to Document

10.1016/j.anl.2020.06.009

Cite this

Kwak, M. Y., Yang, C. J., Shim, H. J., Song, C. I., Kim, J. Y., Lee, I. W., Jung, S. W., Lim, H. W., Kwon, J. K., Lee, J. H., Choi, J., An, Y. S., Lee, K. Y., & Chung, J. W. (2020). Intratympanic steroid injection for sudden sensorineural hearing loss: Impact of injection interval on therapeutic efficacy. Auris Nasus Larynx, 47(6), 982-989. https://doi.org/10.1016/j.anl.2020.06.009

@article{7d1a30c228cd44e78461d1366f0851fb,

title = "Intratympanic steroid injection for sudden sensorineural hearing loss: Impact of injection interval on therapeutic efficacy",

abstract = "Objective: To compare the effect of injection time intervals of intratympanic (IT) dexamethasone (DEX) in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Methods: Seventy-five adults with ISSNHL were grouped into four groups according to the IT DEX interval. In addition to concurrent oral steroid medication for two weeks, patients received IT DEX injections every 1, 2, 3, and four days, respectively. (Group 1, Group 2, Group 3, and Group 4). We evaluated the treatment outcomes according to modified criteria from “Clinical Practice Guideline: Sudden Hearing Loss” of the American Academy of Otolaryngology-Head and Neck Surgery (AAO–HNS) to justify treatment success. Results: There were no significant differences in demographic and baseline audiometric data. The mean of pure tone audiometry (PTA) and speech discrimination score (SDSs) were significantly improved after oral steroid and IT DEX treatment in all four groups. Group 1 showed significantly higher improvement than Group 4 in PTA after treatment. There was a significantly higher complete recovery (CR) rate in Group 1 than Group 4. Conclusion: We found a statistically significant difference in the complete hearing recovery rate and audiometric results (PTA) between the group with a daily interval of injections and the group with a four-day time interval. Therefore, daily time intervals in intratympanic steroid injection may be considered as an option for better improvement of hearing in patients with ISSNHL.",

keywords = "Audiometry, Dexamethasone, Intratympanic, Sudden hearing loss",

author = "Kwak, {Min Young} and Yang, {Chan Ju} and Shim, {Hyun Joon} and Song, {Chan Il} and Kim, {Jong Yang} and Lee, {Il Woo} and Jung, {Sung Wook} and Lim, {Hyun Woo} and Kwon, {Joong Keun} and Lee, {Jun Ho} and June Choi and An, {Yun Suk} and Lee, {Kyu Yup} and Chung, {Jong Woo}",

note = "Funding Information: This study was supported by a grant ( 2013–0455 ) from the Asan Institute for Life Sciences , Asan Medical Center, Seoul, Korea Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = dec,

doi = "10.1016/j.anl.2020.06.009",

language = "English",

volume = "47",

pages = "982--989",

journal = "Auris Nasus Larynx",

issn = "0385-8146",

publisher = "Elsevier Ireland Ltd",

number = "6",

}

TY - JOUR

T1 - Intratympanic steroid injection for sudden sensorineural hearing loss

T2 - Impact of injection interval on therapeutic efficacy

AU - Kwak, Min Young

AU - Yang, Chan Ju

AU - Shim, Hyun Joon

AU - Song, Chan Il

AU - Kim, Jong Yang

AU - Lee, Il Woo

AU - Jung, Sung Wook

AU - Lim, Hyun Woo

AU - Kwon, Joong Keun

AU - Lee, Jun Ho

AU - Choi, June

AU - An, Yun Suk

AU - Lee, Kyu Yup

AU - Chung, Jong Woo

PY - 2020/12

Y1 - 2020/12

N2 - Objective: To compare the effect of injection time intervals of intratympanic (IT) dexamethasone (DEX) in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Methods: Seventy-five adults with ISSNHL were grouped into four groups according to the IT DEX interval. In addition to concurrent oral steroid medication for two weeks, patients received IT DEX injections every 1, 2, 3, and four days, respectively. (Group 1, Group 2, Group 3, and Group 4). We evaluated the treatment outcomes according to modified criteria from “Clinical Practice Guideline: Sudden Hearing Loss” of the American Academy of Otolaryngology-Head and Neck Surgery (AAO–HNS) to justify treatment success. Results: There were no significant differences in demographic and baseline audiometric data. The mean of pure tone audiometry (PTA) and speech discrimination score (SDSs) were significantly improved after oral steroid and IT DEX treatment in all four groups. Group 1 showed significantly higher improvement than Group 4 in PTA after treatment. There was a significantly higher complete recovery (CR) rate in Group 1 than Group 4. Conclusion: We found a statistically significant difference in the complete hearing recovery rate and audiometric results (PTA) between the group with a daily interval of injections and the group with a four-day time interval. Therefore, daily time intervals in intratympanic steroid injection may be considered as an option for better improvement of hearing in patients with ISSNHL.

AB - Objective: To compare the effect of injection time intervals of intratympanic (IT) dexamethasone (DEX) in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Methods: Seventy-five adults with ISSNHL were grouped into four groups according to the IT DEX interval. In addition to concurrent oral steroid medication for two weeks, patients received IT DEX injections every 1, 2, 3, and four days, respectively. (Group 1, Group 2, Group 3, and Group 4). We evaluated the treatment outcomes according to modified criteria from “Clinical Practice Guideline: Sudden Hearing Loss” of the American Academy of Otolaryngology-Head and Neck Surgery (AAO–HNS) to justify treatment success. Results: There were no significant differences in demographic and baseline audiometric data. The mean of pure tone audiometry (PTA) and speech discrimination score (SDSs) were significantly improved after oral steroid and IT DEX treatment in all four groups. Group 1 showed significantly higher improvement than Group 4 in PTA after treatment. There was a significantly higher complete recovery (CR) rate in Group 1 than Group 4. Conclusion: We found a statistically significant difference in the complete hearing recovery rate and audiometric results (PTA) between the group with a daily interval of injections and the group with a four-day time interval. Therefore, daily time intervals in intratympanic steroid injection may be considered as an option for better improvement of hearing in patients with ISSNHL.

KW - Audiometry

KW - Dexamethasone

KW - Intratympanic

KW - Sudden hearing loss

UR - http://www.scopus.com/inward/record.url?scp=85087673000&partnerID=8YFLogxK

U2 - 10.1016/j.anl.2020.06.009

DO - 10.1016/j.anl.2020.06.009

M3 - Article

AN - SCOPUS:85087673000

SN - 0385-8146

VL - 47

SP - 982

EP - 989

JO - Auris Nasus Larynx

JF - Auris Nasus Larynx

IS - 6

ER -

Intratympanic steroid injection for sudden sensorineural hearing loss: Impact of injection interval on therapeutic efficacy

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this