Investigation of entrapped pore in the pastilles by a mercury porosimetery technique

Jung Woo Kim; Yang Ho Cheon; Danail Donchev; Sung Hyun Kim; Joachim Ulrich

doi:10.1016/j.ijpharm.2004.10.018

Investigation of entrapped pore in the pastilles by a mercury porosimetery technique

Jung Woo Kim, Yang Ho Cheon, Danail Donchev, Sung Hyun Kim, Joachim Ulrich

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The pore in pastilles was investigated which are produced by a pastillation technology. Mercury intrusion porosimeter and scanning electron microscopy (SEM) techniques were used for the investigation. The formation of micro-pores and cracks were in dependence of the manufacturing conditions of the pastilles (final impacting velocity, degree of subcooling and surface roughness of cooled substrate). The total pore is decreased with decreasing degree of subcooling, final impacting velocity and surface roughness of the cooled substrate. In order to design a drug delivery system and to select an optimum manufacturing parameter the relationship between overall growth rate of the pastilles and total pore was experimentally investigated. The total pore increased with increasing the overall growth rate of pastilles.

Original language	English
Pages (from-to)	305-314
Number of pages	10
Journal	International Journal of Pharmaceutics
Volume	288
Issue number	2
DOIs	https://doi.org/10.1016/j.ijpharm.2004.10.018
Publication status	Published - 2005 Jan 20

Keywords

Mercury intrusion porosimetry
Pastillation technology
Pastille
Pore

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/j.ijpharm.2004.10.018

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title = "Investigation of entrapped pore in the pastilles by a mercury porosimetery technique",

abstract = "The pore in pastilles was investigated which are produced by a pastillation technology. Mercury intrusion porosimeter and scanning electron microscopy (SEM) techniques were used for the investigation. The formation of micro-pores and cracks were in dependence of the manufacturing conditions of the pastilles (final impacting velocity, degree of subcooling and surface roughness of cooled substrate). The total pore is decreased with decreasing degree of subcooling, final impacting velocity and surface roughness of the cooled substrate. In order to design a drug delivery system and to select an optimum manufacturing parameter the relationship between overall growth rate of the pastilles and total pore was experimentally investigated. The total pore increased with increasing the overall growth rate of pastilles.",

keywords = "Mercury intrusion porosimetry, Pastillation technology, Pastille, Pore",

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AU - Kim, Jung Woo

AU - Cheon, Yang Ho

AU - Donchev, Danail

AU - Kim, Sung Hyun

AU - Ulrich, Joachim

PY - 2005/1/20

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N2 - The pore in pastilles was investigated which are produced by a pastillation technology. Mercury intrusion porosimeter and scanning electron microscopy (SEM) techniques were used for the investigation. The formation of micro-pores and cracks were in dependence of the manufacturing conditions of the pastilles (final impacting velocity, degree of subcooling and surface roughness of cooled substrate). The total pore is decreased with decreasing degree of subcooling, final impacting velocity and surface roughness of the cooled substrate. In order to design a drug delivery system and to select an optimum manufacturing parameter the relationship between overall growth rate of the pastilles and total pore was experimentally investigated. The total pore increased with increasing the overall growth rate of pastilles.

AB - The pore in pastilles was investigated which are produced by a pastillation technology. Mercury intrusion porosimeter and scanning electron microscopy (SEM) techniques were used for the investigation. The formation of micro-pores and cracks were in dependence of the manufacturing conditions of the pastilles (final impacting velocity, degree of subcooling and surface roughness of cooled substrate). The total pore is decreased with decreasing degree of subcooling, final impacting velocity and surface roughness of the cooled substrate. In order to design a drug delivery system and to select an optimum manufacturing parameter the relationship between overall growth rate of the pastilles and total pore was experimentally investigated. The total pore increased with increasing the overall growth rate of pastilles.

KW - Mercury intrusion porosimetry

KW - Pastillation technology

KW - Pastille

KW - Pore

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Investigation of entrapped pore in the pastilles by a mercury porosimetery technique

Abstract

Keywords

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