Investigation of marine-derived fungal diversity and their exploitable biological activities

Joo Hyun Hong, Seokyoon Jang, Young Mok Heo, Mihee Min, Hwanhwi Lee, Young Min Lee, Hanbyul Lee, Jae Jin Kim

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)


Marine fungi are potential producers of bioactive compounds that may have pharmacological and medicinal applications. Fungi were cultured from marine brown algae and identified using multiple target genes to confirm phylogenetic placement. These target genes included the internal transcribed spacer (ITS), the nuclear large subunit (LSU), and the β-tubulin region. Various biological activities of marine-derived fungi were evaluated, including their antifungal, antioxidant and cellulolytic enzyme activities. As a result, a total of 50 fungi was isolated from the brown algae Sargassum sp. Among the 50 isolated fungi, Corollospora angusta was the dominant species in this study. The genus Arthrinium showed a relatively strong antifungal activity to all of the target plant pathogenic fungi. In particular, Arthrinium saccharicola KUC21221 showed high radical scavenging activity and the highest activities in terms of filter paper units (0.39 U/mL), endoglucanase activity (0.38 U/mL), and β-glucosidase activity (1.04 U/mL).

Original languageEnglish
Pages (from-to)4137-4155
Number of pages19
JournalMarine drugs
Issue number7
Publication statusPublished - 2015 Jul 1

Bibliographical note

Publisher Copyright:
© 2015 by the authors; licensee MDPI, Basel, Switzerland.


  • Antioxidant activity
  • Biological control
  • Cellulolytic enzyme activity
  • Marine fungi
  • Phylogenetic analysis

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)


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