Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells

Hoon Seok Yoon; Sun Ryung Lee; Hee Chul Ko; Soo Youn Choi; Ji Gweon Park; Jeong Kook Kim; Se Jae Kim

doi:10.1271/bbb.70088

Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells

Hoon Seok Yoon, Sun Ryung Lee, Hee Chul Ko, Soo Youn Choi, Ji Gweon Park, Jeong Kook Kim, Se Jae Kim

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.

Original language	English
Pages (from-to)	1781-1784
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	71
Issue number	7
DOIs	https://doi.org/10.1271/bbb.70088
Publication status	Published - 2007

Bibliographical note

Funding Information:
This study was supported by a Research Grant (2005) for Regional Industrial Technology Development from the Ministry of Commerce, Industry, and Energy of the Republic of Korea.

Keywords

Extracellular signal-regulated kinase (ERK)
Melanogenesis
Nobiletin
Tyrosinase

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1271/bbb.70088

Cite this

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title = "Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells",

abstract = "Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.",

keywords = "Extracellular signal-regulated kinase (ERK), Melanogenesis, Nobiletin, Tyrosinase",

author = "Yoon, {Hoon Seok} and Lee, {Sun Ryung} and Ko, {Hee Chul} and Choi, {Soo Youn} and Park, {Ji Gweon} and Kim, {Jeong Kook} and Kim, {Se Jae}",

note = "Funding Information: This study was supported by a Research Grant (2005) for Regional Industrial Technology Development from the Ministry of Commerce, Industry, and Energy of the Republic of Korea.",

year = "2007",

doi = "10.1271/bbb.70088",

language = "English",

volume = "71",

pages = "1781--1784",

journal = "Bioscience, Biotechnology and Biochemistry",

issn = "0916-8451",

publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",

number = "7",

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TY - JOUR

T1 - Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells

AU - Yoon, Hoon Seok

AU - Lee, Sun Ryung

AU - Ko, Hee Chul

AU - Choi, Soo Youn

AU - Park, Ji Gweon

AU - Kim, Jeong Kook

AU - Kim, Se Jae

N1 - Funding Information: This study was supported by a Research Grant (2005) for Regional Industrial Technology Development from the Ministry of Commerce, Industry, and Energy of the Republic of Korea.

PY - 2007

Y1 - 2007

N2 - Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.

AB - Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.

KW - Extracellular signal-regulated kinase (ERK)

KW - Melanogenesis

KW - Nobiletin

KW - Tyrosinase

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DO - 10.1271/bbb.70088

M3 - Article

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AN - SCOPUS:34548449361

SN - 0916-8451

VL - 71

SP - 1781

EP - 1784

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 7

ER -

Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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