Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.
Bibliographical noteFunding Information:
This study was supported by a Research Grant (2005) for Regional Industrial Technology Development from the Ministry of Commerce, Industry, and Energy of the Republic of Korea.
- Extracellular signal-regulated kinase (ERK)
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