Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells

Hoon Seok Yoon, Sun Ryung Lee, Hee Chul Ko, Soo Youn Choi, Ji Gweon Park, Jeong Kook Kim, Se Jae Kim

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.

Original languageEnglish
Pages (from-to)1781-1784
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume71
Issue number7
DOIs
Publication statusPublished - 2007

Bibliographical note

Funding Information:
This study was supported by a Research Grant (2005) for Regional Industrial Technology Development from the Ministry of Commerce, Industry, and Energy of the Republic of Korea.

Keywords

  • Extracellular signal-regulated kinase (ERK)
  • Melanogenesis
  • Nobiletin
  • Tyrosinase

ASJC Scopus subject areas

  • General Medicine

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