Iridoids from Patrinia heterophylla and their anti-inflammatory activity

Wenhui Liu, Peng Wu, Ziteng Song, Fan Nie, Liang Zhang, Dongho Lee, Akira Nakajima, Jing Xu, Yuanqiang Guo

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


A phytochemical investigation led to the isolation of five undescribed compounds (1–5) from the methanol extract of the rhizomes and roots of Patrinia heterophylla. The structures and configurations of these compounds were characterized by HRESIMS, ECD, and NMR data analyses. These compounds were assayed for their anti-inflammatory potential using LPS-stimulated BV-2 cells, of which compound 4 showed strong nitric oxide (NO) inhibitory effects with an IC50 of 6.48 μM. The potential anti-inflammatory mechanism was examined utilizing Western blotting and molecular docking. Further in vivo anti-inflammatory experiments revealed that compound 4 inhibited the NO production and reactive oxygen species in the zebrafish model.

Original languageEnglish
Article number113720
Publication statusPublished - 2023 Aug

Bibliographical note

Funding Information:
This research was supported financially by the National Natural Science Foundation of China (Nos. 22077067 and 22177054 ), the Open Fund of State Key Laboratory of Tea Plant Biology and Utilization ( SKLTOF20190114 , Anhui Agricultural University) , and the 111 Project B20016 .

Publisher Copyright:
© 2023 Elsevier Ltd


  • Anti-inflammation
  • Iridoids
  • NO
  • Patrinia heterophylla Bunge
  • Valerianaceae

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture


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