Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells

Hee jin Jun, Minh Hien Hoang, Jin Woo Lee, Jia Yaoyao, Ji Hae Lee, Dong Ho Lee, Hak Ju Lee, Woo Duck Seo, Bang Yeon Hwang, Sung Joon Lee

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

A novel liver X receptor (LXR) modulator, iristectorigenin B isolated from Belamcanda chinensis, stimulated the transcriptional activity of both LXR-α and LXR-β. In macrophages, iristectorigenin B suppressed cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes, ATP-binding cassette transporters A1 and G1. It did not induce hepatic lipid accumulation nor the expression of the lipogenesis genes sterol regulatory element-binding protein-1c, fatty acid synthase, and stearoyl-CoA desaturase-1. Iristectorigenin B thus is a dual-LXR agonist that regulates the expression of key genes in cholesterol homeostasis in macrophage cells without inducing hepatic lipid accumulation.

Original languageEnglish
Pages (from-to)2213-2221
Number of pages9
JournalBiotechnology letters
Volume34
Issue number12
DOIs
Publication statusPublished - 2012 Nov

Bibliographical note

Funding Information:
Acknowledgments We appreciate the technical assistance of Hea-Won Kim. This study was supported by the Korean Forest Service (Forest Science & Technology Project No. S120909L130110), the Technology Development Program for Fisheries of the Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea (iPET, F20926409H220000110), and the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (20100028180).

Keywords

  • Belamcanda chinensis
  • Cholesterol
  • Iristectorigenin B
  • LXR modulator

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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