Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells

Hee jin Jun; Minh Hien Hoang; Jin Woo Lee; Jia Yaoyao; Ji Hae Lee; Dong Ho Lee; Hak Ju Lee; Woo Duck Seo; Bang Yeon Hwang; Sung Joon Lee

doi:10.1007/s10529-012-1036-y

Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells

Hee jin Jun, Minh Hien Hoang, Jin Woo Lee, Jia Yaoyao, Ji Hae Lee, Dong Ho Lee, Hak Ju Lee, Woo Duck Seo, Bang Yeon Hwang, Sung Joon Lee

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

A novel liver X receptor (LXR) modulator, iristectorigenin B isolated from Belamcanda chinensis, stimulated the transcriptional activity of both LXR-α and LXR-β. In macrophages, iristectorigenin B suppressed cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes, ATP-binding cassette transporters A1 and G1. It did not induce hepatic lipid accumulation nor the expression of the lipogenesis genes sterol regulatory element-binding protein-1c, fatty acid synthase, and stearoyl-CoA desaturase-1. Iristectorigenin B thus is a dual-LXR agonist that regulates the expression of key genes in cholesterol homeostasis in macrophage cells without inducing hepatic lipid accumulation.

Original language	English
Pages (from-to)	2213-2221
Number of pages	9
Journal	Biotechnology letters
Volume	34
Issue number	12
DOIs	https://doi.org/10.1007/s10529-012-1036-y
Publication status	Published - 2012 Nov

Keywords

Belamcanda chinensis
Cholesterol
Iristectorigenin B
LXR modulator

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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10.1007/s10529-012-1036-y

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Jun, H. J., Hoang, M. H., Lee, J. W., Yaoyao, J., Lee, J. H., Lee, D. H., Lee, H. J., Seo, W. D., Hwang, B. Y., & Lee, S. J. (2012). Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells. Biotechnology letters, 34(12), 2213-2221. https://doi.org/10.1007/s10529-012-1036-y

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title = "Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells",

abstract = "A novel liver X receptor (LXR) modulator, iristectorigenin B isolated from Belamcanda chinensis, stimulated the transcriptional activity of both LXR-α and LXR-β. In macrophages, iristectorigenin B suppressed cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes, ATP-binding cassette transporters A1 and G1. It did not induce hepatic lipid accumulation nor the expression of the lipogenesis genes sterol regulatory element-binding protein-1c, fatty acid synthase, and stearoyl-CoA desaturase-1. Iristectorigenin B thus is a dual-LXR agonist that regulates the expression of key genes in cholesterol homeostasis in macrophage cells without inducing hepatic lipid accumulation.",

keywords = "Belamcanda chinensis, Cholesterol, Iristectorigenin B, LXR modulator",

author = "Jun, {Hee jin} and Hoang, {Minh Hien} and Lee, {Jin Woo} and Jia Yaoyao and Lee, {Ji Hae} and Lee, {Dong Ho} and Lee, {Hak Ju} and Seo, {Woo Duck} and Hwang, {Bang Yeon} and Lee, {Sung Joon}",

note = "Funding Information: Acknowledgments We appreciate the technical assistance of Hea-Won Kim. This study was supported by the Korean Forest Service (Forest Science & Technology Project No. S120909L130110), the Technology Development Program for Fisheries of the Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea (iPET, F20926409H220000110), and the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (20100028180).",

year = "2012",

month = nov,

doi = "10.1007/s10529-012-1036-y",

language = "English",

volume = "34",

pages = "2213--2221",

journal = "Biotechnology letters",

issn = "0141-5492",

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T1 - Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells

AU - Jun, Hee jin

AU - Hoang, Minh Hien

AU - Lee, Jin Woo

AU - Yaoyao, Jia

AU - Lee, Ji Hae

AU - Lee, Dong Ho

AU - Lee, Hak Ju

AU - Seo, Woo Duck

AU - Hwang, Bang Yeon

AU - Lee, Sung Joon

N1 - Funding Information: Acknowledgments We appreciate the technical assistance of Hea-Won Kim. This study was supported by the Korean Forest Service (Forest Science & Technology Project No. S120909L130110), the Technology Development Program for Fisheries of the Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea (iPET, F20926409H220000110), and the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (20100028180).

PY - 2012/11

Y1 - 2012/11

N2 - A novel liver X receptor (LXR) modulator, iristectorigenin B isolated from Belamcanda chinensis, stimulated the transcriptional activity of both LXR-α and LXR-β. In macrophages, iristectorigenin B suppressed cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes, ATP-binding cassette transporters A1 and G1. It did not induce hepatic lipid accumulation nor the expression of the lipogenesis genes sterol regulatory element-binding protein-1c, fatty acid synthase, and stearoyl-CoA desaturase-1. Iristectorigenin B thus is a dual-LXR agonist that regulates the expression of key genes in cholesterol homeostasis in macrophage cells without inducing hepatic lipid accumulation.

AB - A novel liver X receptor (LXR) modulator, iristectorigenin B isolated from Belamcanda chinensis, stimulated the transcriptional activity of both LXR-α and LXR-β. In macrophages, iristectorigenin B suppressed cholesterol accumulation in a dose-dependent manner and induced the transcriptional activation of LXR-α/-β-responsive genes, ATP-binding cassette transporters A1 and G1. It did not induce hepatic lipid accumulation nor the expression of the lipogenesis genes sterol regulatory element-binding protein-1c, fatty acid synthase, and stearoyl-CoA desaturase-1. Iristectorigenin B thus is a dual-LXR agonist that regulates the expression of key genes in cholesterol homeostasis in macrophage cells without inducing hepatic lipid accumulation.

KW - Belamcanda chinensis

KW - Cholesterol

KW - Iristectorigenin B

KW - LXR modulator

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AN - SCOPUS:84868448474

SN - 0141-5492

VL - 34

SP - 2213

EP - 2221

JO - Biotechnology letters

JF - Biotechnology letters

IS - 12

ER -

Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells

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