TY - JOUR
T1 - Is stereotactic body radiotherapy for ultra-central lung tumor a feasible option? A systemic review and meta-analysis
AU - Rim, Chai Hong
AU - Kim, Young
AU - Kim, Chul Yong
AU - Yoon, Won Sup
AU - Yang, Dae Sik
N1 - Funding Information:
This work is supported by National research fund of Korea [NRF-2018R1D1A1B07046998].
Publisher Copyright:
© 2019, Copyright © 2019 Taylor & Francis Group LLC.
PY - 2018/12/6
Y1 - 2018/12/6
N2 - Introduction: Ultra-central (UC) tumors, which are generally defined as tumors directly abutting the proximal bronchial tree, are difficult to treat with stereotactic body radiotherapy (SBRT) owing to possible serious complications. This systemic review and meta-analysis analyzed the early experiences and evaluated the efficacy and feasibility of SBRT for UC tumors. Methods and materials: The present study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Systemic searches of the EMBASE, PubMed, MEDLINE, and Cochrane library electronic databases were performed. The primary endpoints were two-year local control (LC), overall survival (OS), and grade ≥3 complication rates. A random-effects model was used to determine the pooled rates of the primary endpoints. Grade 5 complications were descriptively assessed. Results: Nine studies involving 291 patients with UC tumors who underwent SBRT were included. The pooled two-year LC, two-year OS, and grade ≥3 complication rates were 96.7% (95% confidence interval [CI]: 91.0–98.9), 57.7% (95% CI: 32.0–79.8), and 23.2% (95% CI: 11.8–40.5), respectively. The incidence of grade 5 complication was 0–22% and was 0% in three of eight available studies. Hemorrhage (68.2%) was the commonest fatal complication. The risk factors for fatal hemoptysis included anticoagulant use, excessive maximum irradiation dose, endobronchial involvement, squamous histology, and bevacizumab exposure. Conclusions: SBRT for UC tumors confers efficient LC, although the risk of complications was not negligible. Control of possible risk factors of hemorrhage and dose optimization through further studies are warranted.
AB - Introduction: Ultra-central (UC) tumors, which are generally defined as tumors directly abutting the proximal bronchial tree, are difficult to treat with stereotactic body radiotherapy (SBRT) owing to possible serious complications. This systemic review and meta-analysis analyzed the early experiences and evaluated the efficacy and feasibility of SBRT for UC tumors. Methods and materials: The present study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Systemic searches of the EMBASE, PubMed, MEDLINE, and Cochrane library electronic databases were performed. The primary endpoints were two-year local control (LC), overall survival (OS), and grade ≥3 complication rates. A random-effects model was used to determine the pooled rates of the primary endpoints. Grade 5 complications were descriptively assessed. Results: Nine studies involving 291 patients with UC tumors who underwent SBRT were included. The pooled two-year LC, two-year OS, and grade ≥3 complication rates were 96.7% (95% confidence interval [CI]: 91.0–98.9), 57.7% (95% CI: 32.0–79.8), and 23.2% (95% CI: 11.8–40.5), respectively. The incidence of grade 5 complication was 0–22% and was 0% in three of eight available studies. Hemorrhage (68.2%) was the commonest fatal complication. The risk factors for fatal hemoptysis included anticoagulant use, excessive maximum irradiation dose, endobronchial involvement, squamous histology, and bevacizumab exposure. Conclusions: SBRT for UC tumors confers efficient LC, although the risk of complications was not negligible. Control of possible risk factors of hemorrhage and dose optimization through further studies are warranted.
KW - Stereotactic body radiotherapy
KW - central tumor
KW - feasibility
KW - lung cancer
KW - ultra-central tumor
UR - http://www.scopus.com/inward/record.url?scp=85061407137&partnerID=8YFLogxK
U2 - 10.1080/09553002.2019.1552375
DO - 10.1080/09553002.2019.1552375
M3 - Article
C2 - 30676182
AN - SCOPUS:85061407137
SN - 0955-3002
VL - 95
SP - 329
EP - 337
JO - International Journal of Radiation Biology
JF - International Journal of Radiation Biology
IS - 3
ER -