Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder

Jung Jin Kim, Laura Mandelli, Chi Un Pae, Diana De Ronchi, Tae Youn Jun, Chul Lee, In Ho Paik, Ashwin A. Patkar, David Steffens, Alessandro Serretti, Changsu Han

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    Dysbindin gene has been repeatedly associated with psychiatric disorders and schizophrenia in particular. This study aimed to investigate the variants of dysbindin gene in major depressive disorder (MDD). One hundred and eighty eight patients with MDD and 350 controls were investigated for 4 variants within the dysbindin gene (rs3213207 A/G, rs1011313 C/T, rs760761 C/T, and rs2619522 A/C). Haplotype analyses revealed a significant association with MDD (p = 0.0007, protective A-C-T-A and A-C-C-C haplotypes), in particular the effect was due to the rs760761 (C/T) and rs2619522 (A/C) haplotype (p = 0.000026). These results suggest a protective effect of some dysbindin gene haplotypes on the development of MDD. Coupled with previous findings on schizophrenia, our finding suggests that dysbindin gene variants may have a role in the susceptibility to MDD. Adequately powered further studies in different ethnic groups are warranted.

    Original languageEnglish
    Pages (from-to)375-379
    Number of pages5
    JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
    Volume32
    Issue number2
    DOIs
    Publication statusPublished - 2008 Feb 15

    Bibliographical note

    Funding Information:
    This study was supported by a grant of the Korean Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (A050047).

    Keywords

    • Dysbindin gene
    • Haplotype
    • Major depression

    ASJC Scopus subject areas

    • Pharmacology
    • Biological Psychiatry

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