Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder

Jung Jin Kim; Laura Mandelli; Chi Un Pae; Diana De Ronchi; Tae Youn Jun; Chul Lee; In Ho Paik; Ashwin A. Patkar; David Steffens; Alessandro Serretti; Changsu Han

doi:10.1016/j.pnpbp.2007.09.002

Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder

Jung Jin Kim, Laura Mandelli, Chi Un Pae, Diana De Ronchi, Tae Youn Jun, Chul Lee, In Ho Paik, Ashwin A. Patkar, David Steffens, Alessandro Serretti, Changsu Han

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Dysbindin gene has been repeatedly associated with psychiatric disorders and schizophrenia in particular. This study aimed to investigate the variants of dysbindin gene in major depressive disorder (MDD). One hundred and eighty eight patients with MDD and 350 controls were investigated for 4 variants within the dysbindin gene (rs3213207 A/G, rs1011313 C/T, rs760761 C/T, and rs2619522 A/C). Haplotype analyses revealed a significant association with MDD (p = 0.0007, protective A-C-T-A and A-C-C-C haplotypes), in particular the effect was due to the rs760761 (C/T) and rs2619522 (A/C) haplotype (p = 0.000026). These results suggest a protective effect of some dysbindin gene haplotypes on the development of MDD. Coupled with previous findings on schizophrenia, our finding suggests that dysbindin gene variants may have a role in the susceptibility to MDD. Adequately powered further studies in different ethnic groups are warranted.

Original language	English
Pages (from-to)	375-379
Number of pages	5
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	32
Issue number	2
DOIs	https://doi.org/10.1016/j.pnpbp.2007.09.002
Publication status	Published - 2008 Feb 15

Keywords

Dysbindin gene
Haplotype
Major depression

ASJC Scopus subject areas

Pharmacology
Biological Psychiatry

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10.1016/j.pnpbp.2007.09.002

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Kim, J. J., Mandelli, L., Pae, C. U., De Ronchi, D., Jun, T. Y., Lee, C., Paik, I. H., Patkar, A. A., Steffens, D., Serretti, A., & Han, C. (2008). Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32(2), 375-379. https://doi.org/10.1016/j.pnpbp.2007.09.002

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title = "Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder",

abstract = "Dysbindin gene has been repeatedly associated with psychiatric disorders and schizophrenia in particular. This study aimed to investigate the variants of dysbindin gene in major depressive disorder (MDD). One hundred and eighty eight patients with MDD and 350 controls were investigated for 4 variants within the dysbindin gene (rs3213207 A/G, rs1011313 C/T, rs760761 C/T, and rs2619522 A/C). Haplotype analyses revealed a significant association with MDD (p = 0.0007, protective A-C-T-A and A-C-C-C haplotypes), in particular the effect was due to the rs760761 (C/T) and rs2619522 (A/C) haplotype (p = 0.000026). These results suggest a protective effect of some dysbindin gene haplotypes on the development of MDD. Coupled with previous findings on schizophrenia, our finding suggests that dysbindin gene variants may have a role in the susceptibility to MDD. Adequately powered further studies in different ethnic groups are warranted.",

keywords = "Dysbindin gene, Haplotype, Major depression",

author = "Kim, {Jung Jin} and Laura Mandelli and Pae, {Chi Un} and {De Ronchi}, Diana and Jun, {Tae Youn} and Chul Lee and Paik, {In Ho} and Patkar, {Ashwin A.} and David Steffens and Alessandro Serretti and Changsu Han",

note = "Funding Information: This study was supported by a grant of the Korean Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (A050047).",

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doi = "10.1016/j.pnpbp.2007.09.002",

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AU - Pae, Chi Un

AU - De Ronchi, Diana

AU - Jun, Tae Youn

AU - Lee, Chul

AU - Paik, In Ho

AU - Patkar, Ashwin A.

AU - Steffens, David

AU - Serretti, Alessandro

AU - Han, Changsu

N1 - Funding Information: This study was supported by a grant of the Korean Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (A050047).

PY - 2008/2/15

Y1 - 2008/2/15

N2 - Dysbindin gene has been repeatedly associated with psychiatric disorders and schizophrenia in particular. This study aimed to investigate the variants of dysbindin gene in major depressive disorder (MDD). One hundred and eighty eight patients with MDD and 350 controls were investigated for 4 variants within the dysbindin gene (rs3213207 A/G, rs1011313 C/T, rs760761 C/T, and rs2619522 A/C). Haplotype analyses revealed a significant association with MDD (p = 0.0007, protective A-C-T-A and A-C-C-C haplotypes), in particular the effect was due to the rs760761 (C/T) and rs2619522 (A/C) haplotype (p = 0.000026). These results suggest a protective effect of some dysbindin gene haplotypes on the development of MDD. Coupled with previous findings on schizophrenia, our finding suggests that dysbindin gene variants may have a role in the susceptibility to MDD. Adequately powered further studies in different ethnic groups are warranted.

AB - Dysbindin gene has been repeatedly associated with psychiatric disorders and schizophrenia in particular. This study aimed to investigate the variants of dysbindin gene in major depressive disorder (MDD). One hundred and eighty eight patients with MDD and 350 controls were investigated for 4 variants within the dysbindin gene (rs3213207 A/G, rs1011313 C/T, rs760761 C/T, and rs2619522 A/C). Haplotype analyses revealed a significant association with MDD (p = 0.0007, protective A-C-T-A and A-C-C-C haplotypes), in particular the effect was due to the rs760761 (C/T) and rs2619522 (A/C) haplotype (p = 0.000026). These results suggest a protective effect of some dysbindin gene haplotypes on the development of MDD. Coupled with previous findings on schizophrenia, our finding suggests that dysbindin gene variants may have a role in the susceptibility to MDD. Adequately powered further studies in different ethnic groups are warranted.

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Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder

Abstract

Keywords

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